Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R B Perry, Xin Yuan, Robert A Scott, Peter Henneman, Iris M Heid, Jorge R Kizer, Leo-Pekka Lyytikäinen and 560 more
Synthesis in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 305 papers, 24 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 24 pooled it
30.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
305 citing papers in PubMed, 24 syntheses or guidelines pooled it, 508 citations in OpenAlex.
245 more citing papers are in PubMed but not listed here.
4 · The record
Corrections and comments
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5 · Who and what money
Authors and funding
570 authors at 20 institutions in 12 countries.
Zari DastaniDepartment of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada.
Marie-France Hivert
Nicholas Timpson
John R B Perry
Xin Yuan
Robert A Scott
Peter Henneman
Iris M Heid
Jorge R Kizer
Leo-Pekka Lyytikäinen
Christian Fuchsberger
Toshiko Tanaka
Andrew P Morris
Kerrin Small
Aaron Isaacs
Marian Beekman
Stefan Coassin
Kurt Lohman
Lu Qi
Stavroula Kanoni
James S Pankow
Hae-Won Uh
Ying Wu
Aurelian Bidulescu
Laura J Rasmussen-Torvik
Celia M T Greenwood
Martin Ladouceur
Jonna Grimsby
Alisa K Manning
Ching-Ti Liu
Jaspal Kooner
Vincent E Mooser
Peter Vollenweider
Karen A Kapur
John Chambers
Nicholas J Wareham
Claudia Langenberg
Rune Frants
Ko Willems-Vandijk
Ben A Oostra
Sara M Willems
Claudia Lamina
Thomas W Winkler
Bruce M Psaty
Russell P Tracy
Jennifer Brody
Ida Chen
Jorma Viikari
Mika Kähönen
Peter P Pramstaller
David M Evans
Beate St Pourcain
Naveed Sattar
Andrew R Wood
Stefania Bandinelli
Olga D Carlson
Josephine M Egan
Stefan Böhringer
Diana van Heemst
Lyudmyla Kedenko
Kati Kristiansson
Marja-Liisa Nuotio
Britt-Marie Loo
Tamara Harris
Melissa Garcia
Alka Kanaya
Margot Haun
Norman Klopp
H-Erich Wichmann
Panos Deloukas
Efi Katsareli
David J Couper
Bruce B Duncan
Margreet Kloppenburg
Linda S Adair
Judith B Borja
DIAGRAM+ Consortium
MAGIC Consortium
GLGC Investigators
MuTHER Consortium
James G Wilson
Solomon Musani
Xiuqing Guo
Toby Johnson
Robert Semple
Tanya M Teslovich
Matthew A Allison
Susan Redline
Sarah G Buxbaum
Karen L Mohlke
Ingrid Meulenbelt
Christie M Ballantyne
George V Dedoussis
Frank B Hu
Yongmei Liu
Bernhard Paulweber
Timothy D Spector
P Eline Slagboom
Luigi Ferrucci
Antti Jula
Markus Perola
Olli Raitakari
Jose C Florez
Veikko Salomaa
Johan G Eriksson
Timothy M Frayling
Andrew A Hicks
Terho Lehtimäki
George Davey Smith
David S Siscovick
Florian Kronenberg
Cornelia van Duijn
Ruth J F Loos
Dawn M Waterworth
James B Meigs
Josee Dupuis
J Brent Richards
Benjamin F Voight
Laura J Scott
Valgerdur Steinthorsdottir
Christian Dina
Ryan P Welch
Eleftheria Zeggini
Cornelia Huth
Yurii S Aulchenko
Gudmar Thorleifsson
Laura J McCulloch
Teresa Ferreira
Harald Grallert
Najaf Amin
Guanming Wu
Cristen J Willer
Soumya Raychaudhuri
Steve A McCarroll
Oliver M Hofmann
Ayellet V Segrè
Mandy van Hoek
Pau Navarro
Kristin Ardlie
Beverley Balkau
Rafn Benediktsson
Amanda J Bennett
Roza Blagieva
Eric Boerwinkle
Lori L Bonnycastle
Kristina Bengtsson Boström
Bert Bravenboer
Suzannah Bumpstead
Noël P Burtt
Guillaume Charpentier
Peter S Chines
Marilyn Cornelis
Gabe Crawford
Alex S F Doney
Katherine S Elliott
Amanda L Elliott
Michael R Erdos
Caroline S Fox
Christopher S Franklin
Martha Ganser
Christian Gieger
Niels Grarup
Todd Green
Simon Griffin
Christopher J Groves
Candace Guiducci
Samy Hadjadj
Neelam Hassanali
Christian Herder
Bo Isomaa
Anne U Jackson
Paul R V Johnson
Torben Jørgensen
Wen H L Kao
Augustine Kong
Peter Kraft
Johanna Kuusisto
Torsten Lauritzen
Man Li
Aloysius Lieverse
Cecilia M Lindgren
Valeriya Lyssenko
Michel Marre
Thomas Meitinger
Kristian Midthjell
Mario A Morken
Narisu Narisu
Peter Nilsson
Katharine R Owen
Felicity Payne
Ann-Kristin Petersen
Carl Platou
Christine Proença
Inga Prokopenko
Wolfgang Rathmann
N William Rayner
Neil R Robertson
Ghislain Rocheleau
Michael Roden
Michael J Sampson
Richa Saxena
Beverley M Shields
Peter Shrader
Gunnar Sigurdsson
Thomas Sparsø
Klaus Strassburger
Heather M Stringham
Qi Sun
Amy J Swift
Barbara Thorand
Jean Tichet
Tiinamaija Tuomi
Rob M van Dam
Timon W van Haeften
Thijs van Herpt
Jana V van Vliet-Ostaptchouk
G Bragi Walters
Michael N Weedon
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Jacqueline Witteman
Richard N Bergman
Stephane Cauchi
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Anna L Gloyn
Ulf Gyllensten
Torben Hansen
Winston A Hide
Graham A Hitman
Albert Hofman
David J Hunter
Kristian Hveem
Markku Laakso
Andrew D Morris
Colin N A Palmer
Igor Rudan
Eric Sijbrands
Lincoln D Stein
Jaakko Tuomilehto
Andre Uitterlinden
Mark Walker
Richard M Watanabe
Goncalo R Abecasis
Bernhard O Boehm
Harry Campbell
Mark J Daly
Andrew T Hattersley
Oluf Pedersen
Inês Barroso
Leif Groop
Rob Sladek
Unnur Thorsteinsdottir
James F Wilson
Thomas Illig
Philippe Froguel
Cornelia M van Duijn
Kari Stefansson
David Altshuler
Michael Boehnke
Mark I McCarthy
Nicole Soranzo
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Nabila Bouatia-Naji
Reedik Mägi
Joshua Randall
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Denis Rybin
Abbas Dehghan
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Kijoung Song
Anuj Goel
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Meena Kumari
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Ping An
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Jerome Delplanque
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Göran Hallmans
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Robert Mahley
Massimo Mangino
María Teresa Martínez-Larrad
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John F Peden
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Laila Simpson
Andrew Singleton
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Amy Swift
Holly Syddall
Ann-Christine Syvänen
Anke Tönjes
André G Uitterlinden
Ko Willems van Dijk
Dhiraj Varma
Sophie Visvikis-Siest
Veronique Vitart
Nicole Vogelzangs
Gérard Waeber
Peter J Wagner
Andrew Walley
Kim L Ward
Hugh Watkins
Sarah H Wild
Gonneke Willemsen
Jaqueline C M Witteman
John W G Yarnell
Diana Zelenika
Björn Zethelius
Guangju Zhai
Jing Hua Zhao
M Carola Zillikens
DIAGRAM Consortium
GIANT Consortium
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Ingrid B Borecki
Pierre Meneton
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David M Nathan
Gordon H Williams
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Peter Schwarz
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Fredrik Karpe
Alan R Shuldiner
Cyrus Cooper
Manuel Serrano-Ríos
Lars Lind
Lyle J Palmer
Frank B Hu
Paul W Franks
Shah Ebrahim
Michael Marmot
W H Linda Kao
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Edward G Lakatta
Reijo Laaksonen
Kirsten O Kyvik
Inke R König
Kay-Tee Khaw
Lee M Kaplan
Åsa Johansson
A Cecile J W Janssens
Wilmar Igl
G Kees Hovingh
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Anna F Dominiczak
Serkalem Demissie
Panagiotis Deloukas
Ulf de Faire
Gabriel Crawford
Yii-der I Chen
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S Matthijs Boekholdt
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Thomas Quertermous
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Tien Y Wong
E-Shyong Tai
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Christopher W Kuzawa
Herman A Taylor
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Vilmundur Gudnason
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Nilesh J Samani
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L Adrienne Cupples
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Sekar Kathiresan
Leiden University Medical Center · NLUniversity of Helsinki · FIUniversity of North Carolina at Chapel Hill · USInnsbruck Medical University · ATBoston University · USErasmus MC · NLKing's College London · GBUniversity of Bristol · GBAddenbrooke's Hospital · GBEurac Research · ITGlaxoSmithKline (United States) · USNational Institute on Aging · USBrigham and Women's Hospital · USBroad Institute · USCedars-Sinai Medical Center · USCentre for Human Genetics · GBFinnish Institute for Health and Welfare · FIHarokopio University of Athens · GRHarvard University · USHelmholtz Zentrum München · DE
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Biotechnology and Biological Sciences Research Council G20234British Heart Foundation PG/08/094/26019British Heart Foundation PG/09/002/26056British Heart Foundation RG/07/008/23674Chief Scientist Office CZB/4/710CIHRDepartment of Health DHCS/07/07/008FIC NIH HHS R01 TW005596FIC NIH HHS TW05596Intramural NIH HHSMedical Research Council G0100222Medical Research Council G0401527Medical Research Council G0600705Medical Research Council G0600717Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G0701863Medical Research Council G0800582Medical Research Council G0801056Medical Research Council G0900339Medical Research Council G0901213Medical Research Council G0902037Medical Research Council G1000143Medical Research Council G19/35Medical Research Council G8802774Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696Medical Research Council MC_U106179471Medical Research Council MC_U127561128Medical Research Council MC_U127592696Medical Research Council MC_U137686857Medical Research Council MC_U147585824Medical Research Council MC_UP_A100_1003Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000454NCRR NIH HHS M01 RR000425NCRR NIH HHS M01-RR00425NCRR NIH HHS P20 RR020649NCRR NIH HHS RR-024156NCRR NIH HHS RR20649NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1 RR025008NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS T32 HG000040NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHLBI NIH HHS HL085144NHLBI NIH HHS HL094555NHLBI NIH HHS HL105756NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01 HC095170NHLBI NIH HHS N01 HC095171NHLBI NIH HHS N01 HC095172NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01-HC-55015NHLBI NIH HHS N01-HC-55016NHLBI NIH HHS N01-HC-55018NHLBI NIH HHS N01-HC-55019NHLBI NIH HHS N01-HC-55020NHLBI NIH HHS N01-HC-55021NHLBI NIH HHS N01-HC-55022NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-65226NHLBI NIH HHS N01-HC-75150NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85080NHLBI NIH HHS N01-HC-85081NHLBI NIH HHS N01-HC-85082NHLBI NIH HHS N01-HC-85083NHLBI NIH HHS N01-HC-85084NHLBI NIH HHS N01-HC-85085NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N01 HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N01-HC-95170NHLBI NIH HHS N01-HC-95171NHLBI NIH HHS N01-HC-95172NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01-HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL094555NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL59367NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL080295NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG032098NICHD NIH HHS R24 HD050924NIDDK NIH HHS 1 R01 DK075787-01A1NIDDK NIH HHS DK063491NIDDK NIH HHS DK078150NIDDK NIH HHS DK56350NIDDK NIH HHS K08 DK002600NIDDK NIH HHS K24 DK080140NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK056918NIDDK NIH HHS R01DK056918NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK078150NIEHS NIH HHS ES10126NIEHS NIH HHS P30 ES010126NIMHD NIH HHS P20 MD006899The Dunhill Medical Trust R69/0208Wellcome Trust 064890Wellcome Trust 081682Wellcome Trust 090532Wellcome Trust 092731
6 · The paper itself
Abstract
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
Indexed as
Genome-Wide Association StudyAdiponectinAsian PeopleBlack or African AmericanCholesterol, HDLDiabetes Mellitus, Type 2FemaleGene ExpressionGenetic Predisposition to DiseaseGlucose Tolerance TestHumansInsulin ResistanceMaleMetabolic Networks and PathwaysPolymorphism, Single NucleotideWaist-Hip RatioAdiponectinCholesterol, HDL
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. · full record | OpenQuestion