ArticlePLoS genetics2012
The transcription factor ultraspiracle influences honey bee social behavior and behavior-related gene expression.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Variation in behavioural maturation in tropical honey bees corresponds with hormonal and molecular differences.The Journal of experimental biology · 2026Article
- Susceptibility to the Neonicotinoid Pesticide Imidacloprid Is Linked to Life History Regulation in Honey Bees (Apis mellifera L.).Molecular ecology · 2026Article
- Cuticle protein mediates the evolution of stress resistance by generating a decoy circular RNA in spider mite.Science advances · 2025Article
- Interactions of juvenile hormone, 20-hydroxyecdysone, developmental genes, and miRNAs during pupal development in Apis mellifera.Scientific reports · 2025Article
- Effects of microRNA-305 knockdown on brain gene expression associated with division of labor in honey bee colonies (Apis mellifera).The Journal of experimental biology · 2024Article
- Gut microbiota contribute to variations in honey bee foraging intensity.The ISME journal · 2024Article
- Brain Gene Expression of Foraging Behavior and Social Environment in Ceratina calcarata.Genome biology and evolution · 2023Article
- Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior.Scientific reports · 2023Article
- Chromatin accessibility-based characterisation of brain gene regulatory networks in three distinct honey bee polyphenisms.Nucleic acids research · 2022Article
- Behavioral genetics and genomics: Mendel's peas, mice, and bees.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Organ-specific transcriptome analysis reveals differential gene expression in different castes under natural conditions in Apis cerana.Scientific reports · 2021Article
- Gene expression and epigenetics reveal species-specific mechanisms acting upon common molecular pathways in the evolution of task division in bees.Scientific reports · 2021Article
- Effects of Dinotefuran on Brain miRNA Expression Profiles in Young Adult Honey Bees (Hymenopptera: Apidae).Journal of insect science (Online) · 2021Article
- Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks.eLife · 2020Article
- Transcriptome analysis of a social caterpillar, Drepana arcuata: De novo assembly, functional annotation and developmental analysis.PloS one · 2020Article
- The transcriptomic signature of low aggression in honey bees resembles a response to infection.BMC genomics · 2019Article
- Division of labor in honey bees is associated with transcriptional regulatory plasticity in the brain.The Journal of experimental biology · 2019Article
- Comparative Analysis of Brain and Fat Body Gene Splicing Patterns in the Honey Bee,G3 (Bethesda, Md.) · 2019Article
- Molecular evolution of juvenile hormone esterase-like proteins in a socially exchanged fluid.Scientific reports · 2018Article
- Genetic accommodation and the role of ancestral plasticity in the evolution of insect eusociality.The Journal of experimental biology · 2018Review
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13 authors.
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Abstract
Behavior is among the most dynamic animal phenotypes, modulated by a variety of internal and external stimuli. Behavioral differences are associated with large-scale changes in gene expression, but little is known about how these changes are regulated. Here we show how a transcription factor (TF), ultraspiracle (usp; the insect homolog of the Retinoid X Receptor), working in complex transcriptional networks, can regulate behavioral plasticity and associated changes in gene expression. We first show that RNAi knockdown of USP in honey bee abdominal fat bodies delayed the transition from working in the hive (primarily "nursing" brood) to foraging outside. We then demonstrate through transcriptomics experiments that USP induced many maturation-related transcriptional changes in the fat bodies by mediating transcriptional responses to juvenile hormone. These maturation-related transcriptional responses to USP occurred without changes in USP's genomic binding sites, as revealed by ChIP-chip. Instead, behaviorally related gene expression is likely determined by combinatorial interactions between USP and other TFs whose cis-regulatory motifs were enriched at USP's binding sites. Many modules of JH- and maturation-related genes were co-regulated in both the fat body and brain, predicting that usp and cofactors influence shared transcriptional networks in both of these maturation-related tissues. Our findings demonstrate how "single gene effects" on behavioral plasticity can involve complex transcriptional networks, in both brain and peripheral tissues.
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