Evidence map›Paper›PMID 22479191›Full record

SynthesisPLoS genetics2012

Genome-wide association and functional follow-up reveals new loci for kidney function.

Cristian Pattaro, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A Böger, Christian Fuchsberger, Matthias Olden, Ming-Huei Chen, Adrienne Tin, Daniel Taliun and 160 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 19 pooled it
29.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 19 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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  6. Pathway Analysis of Renal Cell Carcinoma Genome-Wide Association Studies Identifies Novel Associations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
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  10. Journal of the American Society of Nephrology : JASN · 2017
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  11. Genetic invalidation of Lp-PLAEuropean journal of preventive cardiology · 2017
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  13. Glycosylation Profile of IgG in Moderate Kidney Dysfunction.Journal of the American Society of Nephrology : JASN · 2016
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  18. Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis.Journal of the American Society of Nephrology : JASN · 2014
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  20. Trial

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

170 authors at 20 institutions in 15 countries.

Cristian PattaroInstitute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy.
Anna Köttgen
Alexander Teumer
Maija Garnaas
Carsten A Böger
Christian Fuchsberger
Matthias Olden
Ming-Huei Chen
Adrienne Tin
Daniel Taliun
Man Li
Xiaoyi Gao
Mathias Gorski
Qiong Yang
Claudia Hundertmark
Meredith C Foster
Conall M O'Seaghdha
Nicole Glazer
Aaron Isaacs
Ching-Ti Liu
Albert V Smith
Jeffrey R O'Connell
Maksim Struchalin
Toshiko Tanaka
Guo Li
Andrew D Johnson
Hinco J Gierman
Mary Feitosa
Shih-Jen Hwang
Elizabeth J Atkinson
Kurt Lohman
Marilyn C Cornelis
Åsa Johansson
Anke Tönjes
Abbas Dehghan
Vincent Chouraki
Elizabeth G Holliday
Rossella Sorice
Zoltan Kutalik
Terho Lehtimäki
Tõnu Esko
Harshal Deshmukh
Sheila Ulivi
Audrey Y Chu
Federico Murgia
Stella Trompet
Medea Imboden
Barbara Kollerits
Giorgio Pistis
CARDIoGRAM Consortium
ICBP Consortium
CARe Consortium
Wellcome Trust Case Control Consortium 2 (WTCCC2)
Tamara B Harris
Lenore J Launer
Thor Aspelund
Gudny Eiriksdottir
Braxton D Mitchell
Eric Boerwinkle
Helena Schmidt
Margherita Cavalieri
Madhumathi Rao
Frank B Hu
Ayse Demirkan
Ben A Oostra
Mariza de Andrade
Stephen T Turner
Jingzhong Ding
Jeanette S Andrews
Barry I Freedman
Wolfgang Koenig
Thomas Illig
Angela Döring
H-Erich Wichmann
Ivana Kolcic
Tatijana Zemunik
Mladen Boban
Cosetta Minelli
Heather E Wheeler
Wilmar Igl
Ghazal Zaboli
Sarah H Wild
Alan F Wright
Harry Campbell
David Ellinghaus
Ute Nöthlings
Gunnar Jacobs
Reiner Biffar
Karlhans Endlich
Florian Ernst
Georg Homuth
Heyo K Kroemer
Matthias Nauck
Sylvia Stracke
Uwe Völker
Henry Völzke
Peter Kovacs
Michael Stumvoll
Reedik Mägi
Albert Hofman
Andre G Uitterlinden
Fernando Rivadeneira
Yurii S Aulchenko
Ozren Polasek
Nick Hastie
Veronique Vitart
Catherine Helmer
Jie Jin Wang
Daniela Ruggiero
Sven Bergmann
Mika Kähönen
Jorma Viikari
Tiit Nikopensius
Michael Province
Shamika Ketkar
Helen Colhoun
Alex Doney
Antonietta Robino
Franco Giulianini
Bernhard K Krämer
Laura Portas
Ian Ford
Brendan M Buckley
Martin Adam
Gian-Andri Thun
Bernhard Paulweber
Margot Haun
Cinzia Sala
Marie Metzger
Paul Mitchell
Marina Ciullo
Stuart K Kim
Peter Vollenweider
Olli Raitakari
Andres Metspalu
Colin Palmer
Paolo Gasparini
Mario Pirastu
J Wouter Jukema
Nicole M Probst-Hensch
Florian Kronenberg
Daniela Toniolo
Vilmundur Gudnason
Alan R Shuldiner
Josef Coresh
Reinhold Schmidt
Luigi Ferrucci
David S Siscovick
Cornelia M van Duijn
Ingrid Borecki
Sharon L R Kardia
Yongmei Liu
Gary C Curhan
Igor Rudan
Ulf Gyllensten
James F Wilson
Andre Franke
Peter P Pramstaller
Rainer Rettig
Inga Prokopenko
Jacqueline C M Witteman
Caroline Hayward
Paul Ridker
Afshin Parsa
Murielle Bochud
Iris M Heid
Wolfram Goessling
Daniel I Chasman
W H Linda Kao
Caroline S Fox
Erasmus MC · NLBrigham and Women's Hospital · USUniversität Greifswald · DEHelmholtz Zentrum München · DEJohns Hopkins University · USWake Forest University · USWashington University in St. Louis · USBoston University · USChristian-Albrechts-Universität zu Kiel · DEEurac Research · ITSwiss Tropical and Public Health Institute · CHUniversity of Dundee · GBUniversity of Edinburgh · GBUniversity of Maryland, Baltimore · USUniversity of Split · HRUppsala University · SEWestern General Hospital · GBEstonian Biocentre · EEInnsbruck Medical University · ATInstitute of Genetics and Biophysics · IT

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Pharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI ONUKWUGHA, EBERECHUKWU · 2002 to 2009
$20.2M
Clinical Research Career Development (RMI)K12RR023250 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2005 to 2009
$13.3M
Chief Scientist Office CZB/4/710Intramural NIH HHSMedical Research Council MC_PC_U127561128Medical Research Council MC_U127561128NCI NIH HHS CA 047988NCI NIH HHS P01 CA055075NCI NIH HHS P01CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01CA087969NCI NIH HHS R01 CA047988NCRR NIH HHS K12 RR023250NCRR NIH HHS K12RR023250NCRR NIH HHS M01 RR000425NCRR NIH HHS M01RR00425NCRR NIH HHS M01 RR016500NCRR NIH HHS M01 RR 16500NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01HG004399NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004415NHGRI NIH HHS U01HG004415NHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01HG004422NHGRI NIH HHS U01 HG004423NHGRI NIH HHS U01HG004423NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004436NHGRI NIH HHS U01HG004436NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01HG004446NHGRI NIH HHS U01 HG004726NHGRI NIH HHS U01HG004726NHGRI NIH HHS U01 HG004728NHGRI NIH HHS U01HG004728NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01HG004729NHGRI NIH HHS U01 HG004735NHGRI NIH HHS U01HG004735NHGRI NIH HHS U01 HG004738NHGRI NIH HHS U01HG004738NHGRI NIH HHS U01HG04424NHLBI NIH HHS 5R01HL08770002NHLBI NIH HHS 5R01HL08770003NHLBI NIH HHS 5R01HL08821502NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HL 043851NHLBI NIH HHS HL69757NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-75150NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85080NHLBI NIH HHS N01-HC-85081NHLBI NIH HHS N01-HC-85082NHLBI NIH HHS N01-HC-85083NHLBI NIH HHS N01-HC-85084NHLBI NIH HHS N01-HC-85085NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL088119NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL59367NHLBI NIH HHS R01 HL-87660NHLBI NIH HHS T32 HL007575NHLBI NIH HHS U01 HL069757NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL072515-06NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL084756NHLBI NIH HHS U19 HL069757NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01-AG-1-2100NIA NIH HHS R01 AG018728NIA NIH HHS R01 AG025941NIA NIH HHS R01 AG032098NIA NIH HHS R01 AG18728NIDCR NIH HHS U01 DE018903NIDCR NIH HHS U01DE018903NIDCR NIH HHS U01 DE018993NIDCR NIH HHS U01DE018993NIDDK NIH HHS 1 R01 DK075787-01A1NIDDK NIH HHS 5R01DK06833603NIDDK NIH HHS 5R01DK07568102NIDDK NIH HHS DK063491NIDDK NIH HHS DK66574NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK058845NIDDK NIH HHS R01DK058845NIDDK NIH HHS R01 DK066574NIDDK NIH HHS R01 DK075787NIGMS NIH HHS U01 GM074518NIGMS NIH HHS U01 GM074518-04Wellcome TrustWellcome Trust 085475/08/ZWellcome Trust 085475/B/08/Z
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.

Indexed as

Genome-Wide Association StudyAgedAnimalsATPases Associated with Diverse Cellular ActivitiesBlack or African AmericanCaspase 9Cyclin-Dependent KinasesDEAD-box RNA HelicasesDNA-Binding ProteinsDNA HelicasesFemaleFollow-Up StudiesGene Knockdown TechniquesGlomerular Filtration RateHumansKidneyATPases Associated with Diverse Cellular ActivitiesCASP9 protein, humanCaspase 9CDK12 protein, humanCyclin-Dependent KinasesDDX1 protein, humanDEAD-box RNA HelicasesDNA-Binding ProteinsDNA HelicasesINO80 protein, humanMPPED2 protein, humanPhosphoric Diester Hydrolases

Identifiers

PMID22479191
PMCPMC3315455
OpenAlexW2165238174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.