ReviewImmunologic research2012
The immune system in the aging human.
Review in Immunologic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Meningitis caused by Capnocytophaga canimorsus in a COVID-19 patient: a rare complication of dog bites.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Getting Old Well in Sub Saharan Africa: Exploring the Social and Structural Drivers of Subjective Wellbeing among Elderly Men and Women in Uganda.International journal of environmental research and public health · 2020Article
- Effects of natural aging and gender on pro-inflammatory markers.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Impaired Immune Response in Elderly Burn Patients: New Insights Into the Immune-senescence Phenotype.Annals of surgery · 2016Article
- Competitive SWIFT cluster templates enhance detection of aging changes.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2016Article
- Role of Immune Aging in Susceptibility to West Nile Virus.Methods in molecular biology (Clifton, N.J.) · 2016Review
- Epstein-Barr virus-specific CD8(+) T lymphocytes from diffuse large B cell lymphoma patients are functionally impaired.Clinical and experimental immunology · 2015Article
- Statin, calcium channel blocker and Beta blocker therapy may decrease the incidence of tuberculosis infection in elderly Taiwanese patients with type 2 diabetes.International journal of molecular sciences · 2015Article
- Preoperative assessment of the older surgical patient: honing in on geriatric syndromes.Clinical interventions in aging · 2015Review
- Age-associated Epstein-Barr virus-specific T cell responses in seropositive healthy adults.Clinical and experimental immunology · 2014Article
- The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer's Disease.Immunity & ageing : I & A · 2014Article
- HIV-1 transgenic rats display alterations in immunophenotype and cellular responses associated with aging.PloS one · 2014Article
- Article
- Impact of host age and parity on susceptibility to severe urinary tract infection in a murine model.PloS one · 2014Article
- Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration.Investigative ophthalmology & visual science · 2013Article
- Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes.Immunity & ageing : I & A · 2013Article
- Biomarkers in inflammatory childhood diseases.Mediators of inflammation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the improvement of medical care and hygienic conditions, there has been a tremendous increment in human lifespan. However, many of the elderly (>65 years) display chronic illnesses, and a majority requires frequent and longer hospitalization. The robustness of the immune system to eliminate or control infections is often eroded with advancing age. Nevertheless, some elderly individuals do cope better than others. The origin of these inter-individual differences may come from genetic, lifestyle conditions (nutrition, socio-economic parameters), as well as the type, number and recurrence of pathogens encountered during life. The theory we are supporting is that chronic infections, through life, will induce profound changes in the immune system probably due to unbalanced inflammatory profiles. Persistent viruses such a cytomegalovirus are not eliminated and are a driven force to immune exhaustion. Because of their age, elderly individuals may have seen more of these chronic stimulators and have experienced more reactivation episodes ultimately leading to shrinkage of their repertoire and overall immune robustness. This review integrates updates on immunity with advancing age and its impact on associated clinical conditions.
Indexed as
Identifiers
22477521What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.