ArticleCerebellum (London, England)2012
Altered white matter structure of the dentatorubrothalamic pathway in children with autistic spectrum disorders.
Article in Cerebellum (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals.Cerebellum (London, England) · 2024Pooled it
- Modulation of atypical brain activation during executive functioning in autism: a pharmacological MRI study of tianeptine.Molecular autism · 2021Trial
- Modulation of brain activation during executive functioning in autism with citalopram.Translational psychiatry · 2019Trial
- Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance.Neuro-oncology · 2024Article
- Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism.Frontiers in systems neuroscience · 2023Review
- Delineating the Decussating Dentato-rubro-thalamic Tract and Its Connections in Humans Using Diffusion Spectrum Imaging Techniques.Cerebellum (London, England) · 2022Article
- Regional Alteration within the Cerebellum and the Reorganization of the Cerebrocerebellar System following Poststroke Aphasia.Neural plasticity · 2022Article
- Investigating the Anatomy and Microstructure of the Dentato-rubro-thalamic and Subthalamo-ponto-cerebellar Tracts in Parkinson's Disease.Frontiers in neurology · 2022Article
- Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention.Frontiers in psychology · 2020Article
- The Importance of Cerebellar Connectivity on Simulated Brain Dynamics.Frontiers in cellular neuroscience · 2020Article
- Patterns of Cerebellar Connectivity with Intrinsic Connectivity Networks in Autism Spectrum Disorders.Journal of autism and developmental disorders · 2019Article
- Intrinsic Functional Connectivity of Dentate Nuclei in Autism Spectrum Disorder.Brain connectivity · 2019Article
- Measurement of Projections Between Dentate Nucleus and Contralateral Frontal Cortex in Human Brain Via Diffusion Tensor Tractography.Cerebellum (London, England) · 2019Article
- Cerebellar contributions to biological motion perception in autism and typical development.Human brain mapping · 2017Article
- Resting-State Functional Connectivity Changes Between Dentate Nucleus and Cortical Social Brain Regions in Autism Spectrum Disorders.Cerebellum (London, England) · 2017Article
- Annual Research Review: Understudied populations within the autism spectrum - current trends and future directions in neuroimaging research.Journal of child psychology and psychiatry, and allied disciplines · 2017Review
- Depiction of dentatorubrothalamic tract fibers in patients with Parkinson's disease and multiple sclerosis in deep brain stimulation.BMC research notes · 2016Article
- Regional specificity of aberrant thalamocortical connectivity in autism.Human brain mapping · 2015Article
- Cerebro-cerebellar circuits in autism spectrum disorder.Frontiers in neuroscience · 2015Review
- The first 1000 days of the autistic brain: a systematic review of diffusion imaging studies.Frontiers in human neuroscience · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathological studies have demonstrated decreased Purkinje cells in cerebellar cortex and changes in the dentate nucleus of the cerebellum, the projection target for the Purkinje cells, in autistic spectrum disorders (ASD). The dentatorubrothalamic tract is formed by efferents from the dentate nucleus projecting toward the red nucleus with axon collaterals to this nucleus and continuing to innervate the ventral lateral and ventral anterior nuclei of the thalamus. In the current study, we assessed whether the dentatorubrothalamic tract is altered in ASD using Q-ball imaging (QBI). The QBI tractography was performed in 13 children with high functioning ASD (HFA), 11 children with low functioning ASD (LFA), and 14 typically developing children (TD). Regions of interest in dentate nucleus and red nucleus in both hemispheres were objectively placed to sort bilateral dorsal-rostral (DR), dorsal-caudal (DC), ventral-rostral (VR), and ventral-caudal (VC) portions of the dentatorubrothalamic pathway. Group differences in fractional anisotropy (FA), axial diffusivity, radial diffusivity, and fiber volume of individual pathways were analyzed. Significantly reduced FA was found in children with LFA and HFA, compared to the TD group in tracts originating in all four subdivisions of the right dentate nucleus. Tract-based morphometry (TBM) analysis demonstrated significant reductions of FA in caudal midbrain (p<0.0001), dorsal-caudal dentate (p=0.0013), and ventral-caudal dentate (p=0.0061) on the right in the LFA group. The FA values in TBM segments of right VR and VC pathways were significantly correlated with communication skills in the combined HFA/LFA group, while there was a significant correlation found between TBM segments of right DR pathway and daily living skills (r=0.76; p=0.004). Decreased white matter integrity in dorsal portions of the dentatorubrothalamic tract may be related to motor features in ASD, while changes in the ventral portions are related more to communication behavior.
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Registered trials
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