ReviewInternal and emergency medicine2013
Herbal hepatotoxicity: a hidden epidemic.
Review in Internal and emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 78 citations in OpenAlex.
- Muscle Matters: Dietary Supplement Use and Sarcopenia Risk.Geriatrics (Basel, Switzerland) · 2026Article
- Assessment of Liver and Kidney Safety of Silver Fir (Food science & nutrition · 2026Article
- Herbal, dietary supplements, oligo and trace elements consumption among chronic liver disease patients and caregivers: a cross-sectional study.Internal and emergency medicine · 2026Article
- Article
- Genkwanin glycosides are major active compounds in Phaleria nisidai extract mediating improved glucose homeostasis by stimulating glucose uptake into adipose tissues.Nature communications · 2025Article
- Complementary and Alternative Medicine (CAM) Practices: A Narrative Review Elucidating the Impact on Healthcare Systems, Mechanisms and Paediatric Applications.Healthcare (Basel, Switzerland) · 2024Review
- In silico, anti-inflammatory and acute toxicological evaluation of an indigenous medicinal plant Pterospermum rubiginosum using Sprague-Dawley rats.Laboratory animal research · 2024Article
- Existing status and future advancements of adulteration detection techniques in herbal products.Molecular biology reports · 2024Review
- An Investigation into the Acute and Subacute Toxicity of Extracts ofPlants (Basel, Switzerland) · 2023Article
- Kombucha-Induced Massive Hepatic Necrosis: A Case Report and a Review of Literature.Gastro hep advances · 2023Article
- Herbal therapies in gastrointestinal and hepatic disorders: An evidence-based clinical review.Frontiers in pharmacology · 2022Review
- Considerations about turmeric-associated hepatotoxicity following a series of cases occurred in Italy: is turmeric really a new hepatotoxic substance?Internal and emergency medicine · 2020Article
- Article
- The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity.International journal of molecular sciences · 2018Article
- Weight-loss supplementation and acute liver failure: the case of Garcinia Cambogia.Internal and emergency medicine · 2018Article
- Quality Assessment of Gentiana rigescens from Different Geographical Origins Using FT-IR Spectroscopy Combined with HPLC.Molecules (Basel, Switzerland) · 2017Article
- Insights into the molecular mechanisms of Polygonum multiflorum Thunb-induced liver injury: a computational systems toxicology approach.Acta pharmacologica Sinica · 2017Article
- Considerations regarding the alleged association between Herbalife products and cases of hepatotoxicity.Internal and emergency medicine · 2014Article
- Considerations regarding the alleged association between Herbalife products and cases of hepatotoxicity: a rebuttal.Internal and emergency medicine · 2014Article
- Use of herbal medicinal products among children and adolescents in Germany.BMC complementary and alternative medicine · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complementary and alternative therapies, including herbal products, have become increasingly popular in the general population and among patients and physicians. Regulations and pharmacovigilance regarding herbal drugs are still incomplete and need to be improved. In fact, herbals are commonly marketed on the Internet, and in many countries they are sold as food supplements, which are beyond the control of drug regulatory agencies. In Europe and the U.S., reports of hepatotoxicity from these products, including those advertised for liver diseases, are accumulating. Many herbal drugs are also commonly used in children, and in women during pregnancy and lactation, because they are believed to be "natural" and, therefore, "harmless." One emerging problem is people preferring herbal-based slimming aids to conventional dietary and physical activity. In Italy, the use of non-conventional therapies has been reported for 13.6 % of the population, and 3.7 % freely use herbal drugs, unaware of the risks associated with a potential interaction with prescription drugs. In our review, we discuss the problem of the lack of standardization of herbal drugs, the lack of randomized clinical trials regarding the majority of these products, the unawareness of risks by the patients who buy and use them, and, further, the problem of underreporting. For the most commonly used herbal products and slimming aids, we describe their potential hepatotoxicity mechanisms, the causality assessment necessary for a correct diagnosis, and the clinical patterns for which these products seem to be responsible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.