Evidence map›Paper›PMID 22477031›Full record

ArticleSleep & breathing = Schlaf & Atmung2013

The incidence and prevalence of temporomandibular disorders and posterior open bite in patients receiving mandibular advancement device therapy for obstructive sleep apnea.

Cristina V Perez, Reny de Leeuw, Jeffrey P Okeson, Charles R Carlson, Hsin-Fang Li, Heather M Bush, Donald A Falace

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04050514 nacompletednot on this mapstarted 2019, after this paper: background citation

Side Effects of Two Different Mandibular Advancement Devices (MAD) in the Treatment of Snoring and Obstructive Sleep Apnea Syndrome (OSAS)

TypeinterventionalSponsorUniversity Medicine GreifswaldRan2019 to 2022Enrolled65ConditionsObstructive Sleep Apnea Syndrome, Temporomandibular DisordersArmsH-MAD with a hinge system according to Herbst
NCT06970171 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Acceptance and Side Effects of Two Different Mandibular Advancement Devices (MADs) in the Treatment of Obstructive Sleep Apnea Syndrome (OSAS)

TypeinterventionalSponsorUniversity Medicine GreifswaldRan2025 to 2028Enrolled28ConditionsObstructive Sleep Apnea Syndrome (OSAS)ArmsMAD of the Scheu Dental type with lateral guidance wings (MAD-1), MAD of the Panthera X3 type with lateral guidance wings (MAD-2)
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Comparison of side effects of different mandibular advancement devices for patients with obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
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  18. Review of Etiology of Posterior Open Bite: Is There a Possible Genetic Cause?Clinical, cosmetic and investigational dentistry · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cristina V PerezOrofacial Pain Center, University of Kentucky, Lexington, KY 40536, USA. cristina.perez@uky.edu
Reny de Leeuw
Jeffrey P Okeson
Charles R Carlson
Hsin-Fang Li
Heather M Bush
Donald A Falace
University of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to evaluate the incidence and prevalence of temporomandibular disorders (TMD) in patients receiving a mandibular advancement device (MAD) to treat obstructive sleep apnea using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). In addition, it also aims to assess the development of posterior open bite (POB). MATERIALS AND

methodsData from 167 patients were evaluated at baseline, from 159 patients after 118 days (visit II), from 129 patients after 208 days (visit III), and from 85 patients after 413 days (visit IV). The presence of TMD symptoms was evaluated through a questionnaire. TMD signs were assessed using the RDC/TMD. Clinical evaluation assessed for the presence of POB.

resultsThe prevalence of TMD was 33/167 (19.8 %) at baseline. After an initial decrease to 14.5 % on visit II, the prevalence increased to 19.4 % on visit III and finally demonstrated a decrease to 8.2 % on visit IV. The incidence of TMD was 10.6 % on visit II. This decreased on further visits and only two (1.9 %) patients developed TMD from visit III to visit IV. POB was found to develop with an average incidence of 6.1 % per visit. The prevalence of POB was 5.8 % on visit II, 9.4 % on visit III, and 17.9 % on visit IV.

conclusionThe use of MADs may lead to the development of TMD in a small number of patients. Nevertheless, these signs are most likely transient. Patients with pre-existing signs and symptoms of TMD do not experience significant exacerbation of those signs and symptoms with MAD use. Furthermore, these may actually decrease over time. POB was found to develop in 17.9 % of patients; however, only 28.6 % of these patients were aware of any bite changes.

Indexed as

Occlusal SplintsAdultAgedComorbidityCross-Sectional StudiesDisorders of Excessive SomnolenceFemaleFollow-Up StudiesHumansIncidenceMaleMandibular AdvancementMiddle AgedOpen BiteSleep Apnea, ObstructiveTemporomandibular Joint Dysfunction Syndrome

Identifiers

PMID22477031
OpenAlexW2052492956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.