ArticleMetabolic brain disease2012
Maternal separation enhances object location memory and prevents exercise-induced MAPK/ERK signalling in adult Sprague-Dawley rats.
Article in Metabolic brain disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Neonatal Maternal Separation Induces Sexual Dimorphism in Brain Development: The Influence on Amino Acid Levels and Cognitive Disorders.Biomolecules · 2023Article
- Early Life Stress AffectsInternational journal of molecular sciences · 2022Review
- Early life stress influences basal ganglia dopamine receptors and novel object recognition of adolescent and adult rats.IBRO neuroscience reports · 2022Article
- Involvement of IGF/IGFBP/Erk axis in the exercise-mediated preventive effects on colorectal cancer in rats.International journal of clinical and experimental pathology · 2021Article
- Effect of early maternal separation stress on attention, spatial learning and social interaction behaviour.Experimental brain research · 2019Article
- Resilience and Vulnerability to Trauma: Early Life Interventions Modulate Aversive Memory Reconsolidation in the Dorsal Hippocampus.Frontiers in molecular neuroscience · 2019Article
- Protective and therapeutic effects of exercise on stress-induced memory impairment.The journal of physiological sciences : JPS · 2019Review
- Early-Ethanol Exposure Induced Region-Specific Changes in Metabolic Proteins in the Rat Brain: A Proteomics Study.Journal of molecular neuroscience : MN · 2018Article
- Cognitive Dysfunction in Major Depressive Disorder. A Translational Review in Animal Models of the Disease.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Female rats are resistant to developing the depressive phenotype induced by maternal separation stress.Metabolic brain disease · 2016Article
- The interaction between stress and exercise, and its impact on brain function.Metabolic brain disease · 2014Review
- Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats.Frontiers in behavioral neuroscience · 2014Article
- The impact of voluntary exercise on relative telomere length in a rat model of developmental stress.BMC research notes · 2012Article
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Authors and funding
3 authors.
Funding
Abstract
Early life stress increases the risk of developing psychopathology accompanied by reduced cognitive function in later life. Maternal separation induces anxiety-like behaviours and is associated with impaired memory. On the other hand, exercise has been shown to diminish anxiety-like behaviours and improve cognitive function. The effects of maternal separation and exercise on anxiety, memory and hippocampal proteins were investigated in male Sprague-Dawley rats. Maternal separation produced anxiety-like behaviours which were reversed by exercise. Maternal separation also enhanced object location memory which was not affected by exercise. Exercise did, however, increase synaptophysin and phospho-extracellular signal-regulated kinase (p-ERK) in the hippocampus of non-separated rats and this effect was not observed in maternally separated rats. These findings show that maternal separation selectively enhanced n memory and prevented activation of the MAPK/ERK signalling pathway in the adult rat hippocampus.
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