ArticleJournal of cachexia, sarcopenia and muscle2012
Evolving concepts on the age-related changes in "muscle quality".
Article in Journal of cachexia, sarcopenia and muscle, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Effects of functional task training on physical performance in older adults: a systematic review and meta-analysis.European geriatric medicine · 2026Pooled it
- Changes in body composition with a hypocaloric diet combined with sedentary, moderate and high-intense physical activity: a randomized controlled trial.BMC women's health · 2019Trial
- Age-Associated Changes in the Spectral and Statistical Parameters of Surface Electromyogram of Tibialis Anterior.BioMed research international · 2016Trial
- Knee extensor muscles of active older adults with knee osteoarthritis are smaller and weaker but not more fatigable than healthy older adults: Relevance to physical function.Osteoarthritis and cartilage open · 2026Article
- Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026Article
- Targeting intramyocellular lipids to improve aging muscle function.Lipids in health and disease · 2025Review
- Impact of Sarcopenia on Falls, Mobility Limitation, and Mortality Using the Diagnostic Criteria Proposed in the Korean Working Group on Sarcopenia Guideline.Annals of geriatric medicine and research · 2025Article
- Muscle Mass Index Decline as a Predictor of Lung Function Reduction in the General Population.Journal of cachexia, sarcopenia and muscle · 2025Article
- Cumulative effects of HThe Journal of physiology · 2025Article
- Muscle quality responses to short-term resistance training volume in older adults: an exploratory clinical trial.Frontiers in aging · 2025Article
- Reductions in Motor Unit Firing are Associated with Clinically Meaningful Leg Extensor Weakness in Older Adults.Calcified tissue international · 2024Review
- Muscle quality an evolving concept.Journal of frailty, sarcopenia and falls · 2023Article
- Neuromuscular junction transmission failure in aging and sarcopenia: The nexus of the neurological and muscular systems.Ageing research reviews · 2023Review
- Sarcopenia and Cardiovascular Diseases.Circulation · 2023Review
- Article
- Thoracolumbar fascia deformation during deadlifting and trunk extension in individuals with and without back pain.Frontiers in medicine · 2023Article
- Single muscle fibre contractile function with ageing.The Journal of physiology · 2022Review
- ALDH2 gene polymorphism is associated with fitness in the elderly Japanese population.Journal of physiological anthropology · 2022Article
- A Proposed Method of Converting Gait Speed and TUG Test in Older Subjects.International journal of environmental research and public health · 2022Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The deterioration of skeletal muscle with advancing age has long been anecdotally recognized and has been of scientific interest for more than 150 years. Over the past several decades, the scientific and medical communities have recognized that skeletal muscle dysfunction (e.g., muscle weakness, poor muscle coordination, etc.) is a debilitating and life-threatening condition in the elderly. For example, the age-associated loss of muscle strength is highly associated with both mortality and physical disability. It is well-accepted that voluntary muscle force production is not solely dependent upon muscle size, but rather results from a combination of neurologic and skeletal muscle factors, and that biologic properties of both of these systems are altered with aging. Accordingly, numerous scientists and clinicians have used the term "muscle quality" to describe the relationship between voluntary muscle strength and muscle size. In this review article, we discuss the age-associated changes in the neuromuscular system-starting at the level of the brain and proceeding down to the subcellular level of individual muscle fibers-that are potentially influential in the etiology of dynapenia (age-related loss of muscle strength and power).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.