ReviewCurrent atherosclerosis reports2012
Atherosclerosis, inflammation, genetics, and stem cells: 2012 update.
Review in Current atherosclerosis reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Longitudinal imaging of murine atherosclerosis with 2-deoxy-2-[Scientific reports · 2023Article
- Efficient generation of endothelial cells from induced pluripotent stem cells derived from a patient with peripheral arterial disease.Cell and tissue research · 2022Article
- The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases.Life (Basel, Switzerland) · 2021Review
- Switching of vascular cells towards atherogenesis, and other factors contributing to atherosclerosis: a systematic review.Thrombosis journal · 2020Article
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- Article
- Twenty-First Century Diseases: Commonly Rare and Rarely Common?Antioxidants & redox signaling · 2017Article
- B cells interactions in lipid immune responses: implications in atherosclerotic disease.Lipids in health and disease · 2017Review
- The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis.Frontiers in genetics · 2017Review
- Association of carotid atherosclerosis and recurrent cerebral infarction in the Chinese population: a meta-analysis.Neuropsychiatric disease and treatment · 2017Article
- A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease.PloS one · 2015Article
- Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives.BioMed research international · 2015Review
- Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells.Cell death & disease · 2014Article
- A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease.Integrative medicine (Encinitas, Calif.) · 2014Article
- Proinflammatory and prothrombotic state in subjects with different glucose tolerance status before cardiovascular disease.Journal of diabetes research · 2014Observational
- Vascular hypercontractility and endothelial dysfunction before development of atherosclerosis in moderate dyslipidemia: role for nitric oxide and interleukin-6.American journal of cardiovascular disease · 2014Article
- Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?Age (Dordrecht, Netherlands) · 2014Article
- Pro-inflammatory genetic markers of atherosclerosis.Current atherosclerosis reports · 2013Review
- Sex-specific heritability of spontaneous lipid levels in an extended pedigree of Indian-origin rhesus macaques (Macaca mulatta).PloS one · 2013Article
- Age-associated decline of monocyte insulin sensitivity in diabetic and healthy individuals.Diabetes & vascular disease researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Atherosclerosis is a peculiar form of inflammation triggered by cholesterol-rich lipoproteins and other noxious factors such as cigarette smoke, diabetes mellitus, and hypertension. Genetics also play an important role in the disease, accounting for about 40% of the risk. Of surprise in recent years of post-human genome sequencing, atherosclerosis-relevant genes discovered by non-biased techniques (ie, genome-wide association studies), did not rehash previously suspected pathways of lipid metabolism, diabetes, or hypertension. Instead these studies highlighted genes relevant to mechanisms of inflammation and stem cell biology. Only a minority of implicated genes were linked to lipid and other cardiac risk factor genes. Although such findings do not contradict the fact that atherosclerosis is triggered and exacerbated by elevated lipids, atherosclerosis "new genes" suggest that the mechanism responsible for the development of arterial lesions is more complex than a simple response to injury, where injury is necessary, but perhaps not sufficient, for disease progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.