ArticleThe Journal of infectious diseases2012
HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy.AIDS (London, England) · 2014Trial
- Changes in fat mitochondrial DNA and function in subjects randomized to abacavir-lamivudine or tenofovir DF-emtricitabine with atazanavir-ritonavir or efavirenz: AIDS Clinical Trials Group study A5224s, substudy of A5202.The Journal of infectious diseases · 2013Trial
- Immune-Related Protein and Non-Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection.Journal of extracellular biology · 2025Article
- High-risk alcohol consumption is associated with mitochondrial damage-associated molecular patterns in people living with HIV.Drug and alcohol dependence reports · 2025Article
- SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo.Viruses · 2024Article
- Identification and validation of CCL5 as a key gene in HIV infection and pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2024Article
- Review
- Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening.BMC infectious diseases · 2021Article
- Gene Expression: the Key to Understanding HIV-1 Infection?Microbiology and molecular biology reviews : MMBR · 2020Review
- Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.AIDS research and human retroviruses · 2020Observational
- TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism.Frontiers in endocrinology · 2020Review
- The Pathogenesis of Liver Disease in People Living With Human Immunodeficiency Virus: The Emerging Role of the Microbiome.Clinical liver disease · 2020Review
- Association Between HIV Infection and Mitochondrial DNA Copy Number in Peripheral Blood: A Population-Based, Prospective Cohort Study.The Journal of infectious diseases · 2019Article
- Relationships Between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons With HIV After 96 Weeks of Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Mitochondrial DNA content of peripheral blood mononuclear cells in ART untreated & stavudine/zidovudine treated HIV-1-infected patients.The Indian journal of medical research · 2018Article
- Evaluation of antiretroviral effect on mitochondrial DNA depletion among HIV-infected patients in Bali.HIV/AIDS (Auckland, N.Z.) · 2018Article
- Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy.Mediators of inflammation · 2018Review
- Adipose Tissue in HIV Infection.Comprehensive Physiology · 2017Review
- Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women.Redox biology · 2017Article
- Mechanisms of Accelerated Liver Fibrosis Progression during HIV Infection.Journal of clinical and translational hepatology · 2016Review
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Authors and funding
18 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundAlthough human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) affect mitochondrial DNA (mtDNA) content and function, comprehensive evaluations of their effects on mitochondria in muscle, adipose tissue, and blood cells are limited.
methodsMitochondrial DNA quantification, mitochondrial genome sequencing, and gene expression analysis were performed on muscle, adipose tissue, and peripheral blood mononuclear cell (PBMC) samples from untreated HIV-positive patients, HIV-positive patients receiving nucleoside reverse transcriptase inhibitor (NRTI)-based ART, and HIV-negative controls.
resultsThe adipose tissue mtDNA/nuclear DNA (nDNA) ratio was increased in untreated HIV-infected patients (ratio, 353) and decreased in those receiving ART (ratio, 162) compared with controls (ratio, 255; P < .05 for both comparisons); the difference between the 2 HIV-infected groups was also significant (P = .002). In HIV-infected participants, mtDNA/nDNA in adipose tissue correlated with the level of activation (CD38+ /HLA-DR+) for CD4+ and CD8+ lymphocytes. No significant differences in mtDNA content were noted in muscle or PMBCs among groups. Exploratory DNA microarray analysis identified differential gene expression between patient groups, including a subset of adipose tissue genes.
conclusionsHIV infection and ART have opposing effects on mtDNA content in adipose tissue; immune activation may mediate the effects of HIV, whereas NRTIs likely mediate the effects of ART.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.