ReviewNeurochemical research2012
Multifunctional roles of NAD⁺ and NADH in astrocytes.
Review in Neurochemical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration.Neurochemical research · 2025Review
- Oxidative Stress Induces the Phosphorylation of NADNeurochemical research · 2025Article
- Prognostic Role of Cuproptosis-Related Gene after Intracerebral Hemorrhage in Mice.Cellular and molecular neurobiology · 2025Article
- Glutathione reductase modulates endogenous oxidative stress and affects growth and virulence in Avibacterium paragallinarum.Veterinary research · 2025Article
- Insulin and leptin acutely modulate the energy metabolism of primary hypothalamic and cortical astrocytes.Journal of neurochemistry · 2025Article
- New insights into the antibiofilm activity and mechanism of Mannosylerythritol Lipid-A againstBiofilm · 2024Article
- NADProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment.EBioMedicine · 2020Article
- Equilibrium of the intracellular redox state for improving cell growth and L-lysine yield of Corynebacterium glutamicum by optimal cofactor swapping.Microbial cell factories · 2019Article
- The Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity.Frontiers in cellular neuroscience · 2019Article
- Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases.Frontiers in integrative neuroscience · 2016Review
- Crosstalk of Signaling and Metabolism Mediated by the NAD(+)/NADH Redox State in Brain Cells.Neurochemical research · 2015Review
- Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline.Frontiers in neuroscience · 2014Review
- Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis.Neurochemistry international · 2013Article
- Fueling and imaging brain activation.ASN neuro · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control and maintenance of the intracellular redox state is an essential task for cells and organisms. NAD(+) and NADH constitute a redox pair crucially involved in cellular metabolism as a cofactor for many dehydrogenases. In addition, NAD(+) is used as a substrate independent of its redox-carrier function by enzymes like poly(ADP)ribose polymerases, sirtuins and glycohydrolases like CD38. The activity of these enzymes affects the intracellular pool of NAD(+) and depends in turn on the availability of NAD(+). In addition, both NAD(+) and NADH as well as the NAD(+)/NADH redox ratio can modulate gene expression and Ca(2+) signals. Therefore, the NAD(+)/NADH redox state constitutes an important metabolic node involved in the control of many cellular events ranging from the regulation of metabolic fluxes to cell fate decisions and the control of cell death. This review summarizes the different functions of NAD(+) and NADH with a focus on astrocytes, a pivotal glial cell type contributing to brain metabolism and signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.