ArticleJournal of materials science. Materials in medicine2012
Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery.
Article in Journal of materials science. Materials in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 25 citations in OpenAlex.
- In vitro bioactivity, cytotoxicity, and gene silencing of graphene oxide as a Bcl-2 siRNA carrier in osteosarcoma cells with in vivo inflammatory response.Scientific reports · 2026Article
- Bioactivity, hemocompatibility, and inflammatory response of calcium incorporated sulfonated polyether ether ketone on mouse-derived bone marrow cells.Bioscience reports · 2024Article
- An Investigation of ElectrospunBioinorganic chemistry and applications · 2022Article
- Study on the inflammatory response of PMMA/polystyrene/silica nanocomposite membranes for drug delivery and dental applications.PloS one · 2019Article
- Multifunctional Electrospun Nanofibers for Enhancing Localized Cancer Treatment.Small (Weinheim an der Bergstrasse, Germany) · 2018Review
- Electrospun collagen and its applications in regenerative medicine.Drug delivery and translational research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent advances in electrospinning have resulted in technologies facilitating easy drug entrapment, obtaining high surface area and thereby higher drug loading and release efficacy, burst control as well as the specific morphology which could be controlled according to the desired requirement. The present study focused on the fabrication of collagen/poly(N-isopropyl acrylamide)/chitosan complex with incorporated 5-fluorouracil, an anticancer drug by the method of electrospinning. The effect of chitosan on the fiber morphology and release kinetics was analyzed by varying its concentration. The release kinetics showed that the increase in chitosan concentration delayed the release of the drug from the fiber network. Nano hydroxyapatite was added to the fiber matrix in order to impart bioactivity, which was confirmed by studies in simulated body fluid. The addition of poly(N-isopropyl acrylamide) increased the blood compatibility of the prepared model. Thus, the model prepared to can find potential application in the field of cancer therapy as a drug-delivery agent in post-surgical treatment of cancer and as blood contacting biomaterial.
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Registered trials
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