Trial reportJournal of thrombosis and thrombolysis2012
Screening of cerebral infarction-related genetic markers using a Cox regression analysis between onset age and heterozygosity at randomly selected short tandem repeat loci.
Trial report in Journal of thrombosis and thrombolysis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease.Archives of medical science : AMS · 2020Article
- Analyzing the Relationship between Cohort and Case-Control Study Results Based on Model for Multiple Pathogenic Factors.Computational and mathematical methods in medicine · 2019Article
- Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this paper is to explore whether the heterozygosity at the 9 CODIS short tandem repeats (STR) loci including D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317 and D7S820 is associated with the risk of atherosclerotic cerebral infarction (CI). The DNA samples were collected from patients with CI (n = 72) and people over the age of 90 years without CI (n = 59). Alleles of the STR loci were determined using the STR Profiler Plus PCR amplification kit. The relationship between the age of onset and heterozygosity was determined with the Cox regression method. A correlation between the age of onset and heterozygosity was observed for the D8S1179 locus (p < 0.05). It implied that regions in the vicinity of locus D8S1179 may harbor susceptibility genes for CI. The analysis of heterozygosity for particular loci as genetic markers using our new study design may be an efficient and reliable approach to estimate genetic predispositions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.