Trial reportJournal of thrombosis and thrombolysis2012
Association of lipopolysaccharide-binding protein gene polymorphisms with cerebral infarction in a Chinese population.
Trial report in Journal of thrombosis and thrombolysis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) have been widely known for their role as an important mediator of immune reactions in the development and progression of atherosclerotic (AS) lesions, which play the most important role in the occurrence of cerebral infarction (CI). The lipopolysaccharide (LPS)-lipopolysaccharide binding protein (LBP) compounds connect LPS receptor-CD14 and play an important role in promoting inflammatory reaction through TLRs. This study was designed to study whether LBP genetic polymorphisms are associated with CI risk in a Chinese population. LBP c.291T>C and c.1306T>C single nucleotide polymorphisms (SNPs) were genotyped in 366 CI cases and 200 controls from Changsha by using method of Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Blood lipid and lipoprotein levels were also detected and the intima-media thickness (IMT) of carotid arteries were determined. No significant difference in genotype and allele distribution of the LBP c.291T>C and LBP c.1306T>C polymorphism was observed between the cases and controls (P > 0.05). CI patients carrying the TC genotype for both LBP c.291T>C and c.1306T>C polymorphisms showed higher carotid IMT than those carrying the TT genotype (P < 0.05, respectively). LBP c.291T>C and c.1306T>C polymorphisms were significantly associated with carotid IMT in Changsha, China, but both polymorphisms were not associated with risk of atherosclerotic CI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.