Evidence map›Paper›PMID 22476628›Full record

ArticleHeart and vessels2013

Endomyocardial biopsy in a patient with hemorrhagic pheochromocytoma presenting as inverted Takotsubo cardiomyopathy.

Kohei Iio, Shunpei Sakurai, Tamon Kato, Shigeki Nishiyama, Takeki Hata, Eiichiro Mawatari, Chihiro Suzuki, Kazuhiro Takekoshi, Kayoko Higuchi, Toru Aizawa and 1 more

Abstract readCase Reports
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In one paragraph

Article in Heart and vessels, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Multifaceted roles of neutrophils in cardiac disease.Journal of leukocyte biology · 2025
    Review
  3. The role of inflammation in takotsubo syndrome: A new therapeutic target?Journal of cellular and molecular medicine · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kohei IioDepartment of Cardiology, Aizawa Hospital, 2-5-1 Honjou, Matsumoto, Nagano, 390-8510, Japan. k_110@cc.hirosaki-u.ac.jp
Shunpei Sakurai
Tamon Kato
Shigeki Nishiyama
Takeki Hata
Eiichiro Mawatari
Chihiro Suzuki
Kazuhiro Takekoshi
Kayoko Higuchi
Toru Aizawa
Uichi Ikeda
Aizawa Hospital · JPShinshu University · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 29-year-old female patient presented with shock and dyspnea due to heart failure and pulmonary edema. Echocardiography indicated excessive contraction limited to the left ventricular apex and akinesis of the basal and middle ventricle, which were confirmed by emergency left ventriculography. The finding was diagnostic of inverted Takotsubo cardiomyopathy. An abdominal computed tomography scan showed a tumor in the left adrenal gland with a central low-density area, and the plasma and urinary catecholamines were strikingly elevated. Taken together, these findings suggested the presence of a hemorrhagic pheochromocytoma. A myocardial biopsy in the very acute stage on the day of admission revealed neutrophilic infiltration and contraction-band necrosis, which was indistinguishable from the previously reported pathology in the acute phase of idiopathic Takotsubo cardiomyopathy without pheochromocytoma. The diagnosis of pheochromocytoma in this case was confirmed 7 weeks later by surgical removal of the left adrenal gland with massive hemorrhage at the center of the pheochromocytoma. The marked similarity of the endomyocardial pathology between this case and cases with idiopathic Takotsubo cardiomyopathy strongly points to catecholamine excess as a common causality for Takotsubo cardiomyopathy with or without pheochromocytoma.

Indexed as

AdrenalectomyAdrenal Gland NeoplasmsAdultBiomarkersBiopsyCatecholaminesEchocardiographyElectrocardiographyEndocardiumFemaleHemorrhageHumansMagnetic Resonance ImagingMyocardiumNecrosisNeutrophil InfiltrationBiomarkersCatecholamines

Identifiers

PMID22476628
OpenAlexW2048411142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.