ArticleParasitology research2012
In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Unlocking the Therapeutic Potential of Ellagitannins: A Comprehensive Review of Key Representatives.Molecules (Basel, Switzerland) · 2025Review
- Comprehensive Metabolomics Profiling and Bioactivity Study ofMetabolites · 2025Article
- Dimeric polyphenols to pave the way for new antimalarial drugs.RSC medicinal chemistry · 2023Article
- Assessment of antimalarial medicinal plants used in Nigerian ethnomedicine reveals antimalarial potential ofHeliyon · 2022Article
- Scale-up approach for supercritical fluid extraction with ethanol-water modified carbon dioxide on Phyllanthus niruri for safe enriched herbal extracts.Scientific reports · 2021Article
- Identification of 3,3'-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) Harms.BMC complementary medicine and therapies · 2021Article
- Antiviral Role of Phenolic Compounds against Dengue Virus: A Review.Biomolecules · 2020Review
- Ethnobotanical study of plants used by the traditional healers to treat malaria in Mogovolas district, northern Mozambique.Heliyon · 2020Article
- Mining Sudanese Medicinal Plants for Antiprotozoal Agents.Frontiers in pharmacology · 2020Article
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- Anti-Plasmodium falciparum Activity of Extracts from 10 Cameroonian Medicinal Plants.Medicines (Basel, Switzerland) · 2018Article
- Antiplasmodial Activity of Isolated Polyphenols fromPharmacognosy research · 2017Article
- Antiplasmodial activity of selected medicinal plants used to treat malaria in Ghana.Parasitology research · 2016Article
- The Genus Phyllanthus: An Ethnopharmacological, Phytochemical, and Pharmacological Review.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Extracts fromMedicines (Basel, Switzerland) · 2015Article
- Bioassay-guided isolation and characterization of active antiplasmodial compounds from Murraya koenigii extracts against Plasmodium falciparum and Plasmodium berghei.Parasitology research · 2014Article
- Antiplasmodial activity of ethanolic extracts of some selected medicinal plants from the northwest of Iran.Parasitology research · 2013Article
- Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra.Molecules (Basel, Switzerland) · 2012Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to screen 11 selected traditional medicinal plants from West Africa for their in vitro antiplasmodial activity in order to determine the activity of single and of combination of plant extracts and to examine the activity of isolated pure compounds. Ethanolic and aqueous extracts of the 11 selected plants and pure compounds from Phyllanthus muellerianus and Anogeissus leiocarpus were tested in vitro against Plasmodium falciparum 3D7. Proliferation inhibitory effects were monitored after 48 h. Among the plants and pure compounds investigated in this study, geraniin from P. muellerianus, ellagic, gentisic, and gallic acids from A. leiocarpus, and extracts from A. leiocarpus, P. muellerianus and combination of A. leiocarpus with P. muellerianus affected the proliferation of P. falciparum most potently. Significant inhibitory activity was observed in combination of A. leiocarpus with P. muellerianus (IC(50) = 10.8 μg/ml), in combination of A. leiocarpus with Khaya senegalensis (IC(50) = 12.5 μg/ml), ellagic acid (IC(50) = 2.88 μM), and geraniin (IC(50) = 11.74 μM). In general growth inhibition was concentration-dependent revealing IC(50) values ranging between 10.8 and -40.1 μg/ml and 2.88 and 11.74 μM for plant extracts and pure substances respectively. Comparison with literature sources of in vivo and in vitro toxicity data revealed that thresholds are up to two times higher than the determined IC(50) values. Thus, the present study suggests that geraniin from P. muellerianus; ellagic acid, gallic acid, and gentisic acid from A. leiocarpus; and combination of extracts from A. leiocarpus with either P. muellerianus or K. senegalensis could be a potential option for malaria treatment.
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