ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2013
Nutrition and degeneration of articular cartilage.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 90 citations in OpenAlex.
- Smart functionalized cartilage repair microspheres: Concepts and applications.Materials today. Bio · 2026Review
- A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Qualitative and Quantitative Evaluation of Loose Bodies as a Novel Cell Source for Autologous Chondrocyte Implantation.Orthopaedic journal of sports medicine · 2026Article
- Articular cartilage thickness alterations in hind limb of young and aged PAC1 gene-deficient mice.Cell and tissue research · 2026Article
- Modulation of inflammatory pathways by omega-3 fatty acids in knee joint health for the management of post-traumatic osteoarthritis: a review.Arthritis research & therapy · 2026Review
- Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis.Frontiers in immunology · 2026Review
- Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis.Frontiers in medicine · 2026Article
- Article
- A Comprehensive Review of Auto- and Allogeneic Chondrocyte Transplantation in Animals and Humans From 1965 to 2025.Cartilage · 2025Article
- Engineered exosomal miR140 modulates mitophagy of chondrocytes through targeting CAPN1 to alleviate osteoarthritis.Science China. Life sciences · 2025Article
- Article
- Thick or Thin? Implications of Cartilage Architecture for Osteoarthritis Risk in Sedentary Lifestyles.Biomedicines · 2025Review
- Restoring articular cartilage: insights from structure, composition and development.Nature reviews. Rheumatology · 2025Review
- Innovative approach to recurrent giant cell tumor of the hand: free osteoarticular metatarsal transfer with simplified donor site management.Journal of surgical case reports · 2025Article
- Increased oxidative phosphorylation through pyruvate dehydrogenase kinase 2 deficiency ameliorates cartilage degradation in mice with surgically induced osteoarthritis.Experimental & molecular medicine · 2025Article
- Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study.Experimental and therapeutic medicine · 2024Article
- Alpha-2-Macroglobulin Attenuates Posttraumatic Osteoarthritis Cartilage Damage by Inhibiting Inflammatory Pathways With Modified Intra-articular Drilling in a Yucatan Minipig Model.The American journal of sports medicine · 2024Article
- Principles of musculoskeletal sport injuries for epidemiologists: a review.Injury epidemiology · 2024Review
- Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research.JOR spine · 2023Review
- Bone/cartilage organoid on-chip: Construction strategy and application.Bioactive materials · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo determine the importance of synovial fluid (SF) or subchondral bone marrow (BM) as nutrition sources in cartilage degeneration.
methodsNinety-five-month-old male rabbits were randomly divided into 5 groups according to sources of nutrition: SFBM-both; BM-only; SF-only; None-SFBM; and Free plug (unrestricted). Nutrition to 4-mm-diameter cylindrical osteochondral plugs created on the trochlea of the distal femurs was obstructed by Polyvinyl Chloride (PVC) cap. Cartilage changes were assessed after 4, 8, and 12 weeks by histology, immunohistochemistry, and real-time PCR.
resultsCartilage in the BM-only group suffered the greatest damage, followed by the None-SFBM and SF-only groups. Apoptosis was increased in the BM-only and None-SFBM groups compared with others. Cartilage was significantly thinner at all time points in the BM-only and None-SFBM groups when compared with SFBM-both and Free plug, whereas in the SF-only group, this difference occurred after 8 weeks. Compared with SFBM-both and Free plug, expression of collagen II and aggrecan mRNAs in all groups was decreased but MMP-3 increased, respectively.
conclusionOur data indicate that SF-derived nutrition is the dominant source of sustenance for adult cartilage structure and function. Cartilage damage is observed when the only nutrition source is the BM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.