ReviewJournal of molecular medicine (Berlin, Germany)2012
Infection, mutation, and cancer evolution.
Review in Journal of molecular medicine (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Modeling cancer's ecological and evolutionary dynamics.Medical oncology (Northwood, London, England) · 2023Article
- Searching for the Metabolic Signature of Cancer: A Review from Warburg's Time to Now.Biomolecules · 2022Review
- A Review of the Role of Oral Microbiome in the Development, Detection, and Management of Head and Neck Squamous Cell Cancers.Cancers · 2022Review
- DNA viruses and cancer: insights from evolutionary biology.Virusdisease · 2020Review
- Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review.Facts, views & vision in ObGyn · 2019Review
- The scope of viral causation of human cancers: interpreting virus density from an evolutionary perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Short- and long-term evolution in our arms race with cancer: Why the war on cancer is winnable.Evolutionary applications · 2018Article
- Genetic diversity, inbreeding and cancer.Proceedings. Biological sciences · 2018Review
- Infections and cancer: the "fifty shades of immunity" hypothesis.BMC cancer · 2017Article
- Infection and cancer in multicellular organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- On the apparent rarity of epithelial cancers in captive chimpanzees.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine.Evolutionary applications · 2015Review
- A phylogenetic model for understanding the effect of gene duplication on cancer progression.Nucleic acids research · 2014Article
- Toward a general evolutionary theory of oncogenesis.Evolutionary applications · 2013Article
- The evolution of evolutionary molecular medicine: genomics are transforming evolutionary biology into a science with new importance for modern medicine.Journal of molecular medicine (Berlin, Germany) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An understanding of oncogenesis can be fostered by an integration of mechanistic studies with evolutionary considerations, which help explain why these mechanisms occur. This integration emphasizes infections and mutations as joint essential causes for many cancers. It suggests that infections may play a broader causal role in oncogenesis than has been generally appreciated. An evolutionary perspective also suggests that oncogenic viruses will tend to be transmitted by routes that provide infrequent opportunities for transmission, such as transmission by sexual and salivary contact. Such routes increase the intensity of natural selection for persistence within hosts, and molecular mechanisms for persistence often compromise critical barriers to oncogenesis, particularly cell cycle arrest, apoptosis, and a cap on the total number of divisions that a cell can undergo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.