ArticlePhysical biology2012
Gain control in molecular information processing: lessons from neuroscience.
Article in Physical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Individual yeast cells signal at different levels but each with good precision.Royal Society open science · 2025Article
- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
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- Heterogeneous Temporal Contrast Adaptation in Drosophila Direction-Selective Circuits.Current biology : CB · 2020Article
- Information Thermodynamics for Time Series of Signal-Response Models.Entropy (Basel, Switzerland) · 2019Article
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- Noise processing by microRNA-mediated circuits: The Incoherent Feed-Forward Loop, revisited.Heliyon · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Statistical properties of environments experienced by biological signaling systems in the real world change, which necessitates adaptive responses to achieve high fidelity information transmission. One form of such adaptive response is gain control. Here, we argue that a certain simple mechanism of gain control, understood well in the context of systems neuroscience, also works for molecular signaling. The mechanism allows us to transmit more than 1 bit (on or off) of information about the signal independent of the signal variance. It does not require additional molecular circuitry beyond that already present in many molecular systems, and in particular, it does not depend on existence of feedback loops. The mechanism provides a potential explanation for abundance of ultrasensitive response curves in biological regulatory networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.