Evidence map›Paper›PMID 22475930›Full record

ReviewNature reviews. Cancer2012

Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.

Benjamin J Vakoc, Dai Fukumura, Rakesh K Jain, Brett E Bouma

Registry-linked trialAbstract readReview
In one paragraph

Review in Nature reviews. Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03683004 (Chemotherapy-Related Changes in Neurocognitive Function and Symptoms in Colorectal Cancer Patients), which is not on this map. Cited by 118 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03683004 completednot on this mapstarted 2018, after this paper: background citation

Chemotherapy-Related Changes in Neurocognitive Function and Symptoms in Colorectal Cancer Patients: A Pilot Study

TypeobservationalSponsorUniversity of NebraskaRan2018 to 2020Enrolled40ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Optical coherence tomography in the emergency department setting: a case series.American journal of ophthalmology case reports · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Minimally Invasive Bowel Cancer Detection through Vibrating Microrobot-Induced Elastography.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Exploiting Matrix Stiffness to Overcome Drug Resistance.ACS biomaterials science & engineering · 2024
    Review
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benjamin J VakocWellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. vakoc.benjamin@mgh.harvard.edu
Dai Fukumura
Rakesh K Jain
Brett E Bouma

Funding

Vascular Normalization: Rolse of Perivascular CellsP01CA080124 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L. · 2000 to 2016
$35.0M
TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Probing Tumor Microenvironment Using NanotechnologyR01CA126642 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 2008 to 2012
$8.3M
NO in Tumor Angiogenesis,Microcirculation &Rad.TherapyR01CA096915 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FUKUMURA, DAI · 2002 to 2012
$3.0M
Development of a preclinical optical frequency domain angiography instrumentR01CA163528 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VAKOC, BENJAMIN JAMES · 2012 to 2016
$1.9M
CENTER FOR BIOMEDICAL OCT RESEARCH AND TRANSLATIONP41RR032042 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BOUMA, BRETT E · 2011 to 2011
$1.6M
Image-Guided Laser Therapy for Barrett's EsophagusK25CA127465 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VAKOC, BENJAMIN JAMES · 2007 to 2011
$595k
Doppler Optical Frequency Domain Imaging InstrumentS10RR027070 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FUKUMURA, DAI · 2010 to 2010
$260k
NCI NIH HHS 5K25CA127465NCI NIH HHS K25 CA127465NCI NIH HHS P01 CA080124NCI NIH HHS P01‑CA080124NCI NIH HHS R01 CA096915NCI NIH HHS R01-CA096915NCI NIH HHS R01 CA126642NCI NIH HHS R01-CA126642NCI NIH HHS R01 CA163528NCRR NIH HHS P41 RR032042NCRR NIH HHS S10 RR027070NCRR NIH HHS S10-RR027070NIBIB NIH HHS P41 EB015903NIBIB NIH HHS P41EB015903
6 · The paper itself

Abstract

The past decade has seen dramatic technological advances in the field of optical coherence tomography (OCT) imaging. These advances have driven commercialization and clinical adoption in ophthalmology, cardiology and gastrointestinal cancer screening. Recently, an array of OCT-based imaging tools that have been developed for preclinical intravital cancer imaging applications has yielded exciting new capabilities to probe and to monitor cancer progression and response in vivo. Here, we review these results, forecast the future of OCT for preclinical cancer imaging and discuss its exciting potential to translate to the clinic as a tool for monitoring cancer therapy.

Indexed as

AnimalsAntinematodal AgentsEarly Detection of CancerHumansNeoplasmsTomography, Optical CoherenceAntinematodal Agents

Identifiers

PMID22475930
PMCPMC3560400

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.