ArticleJournal of biological regulators and homeostatic agents
Pharmacological manipulation of the dopaminergic system affects wheel-running activity in differentially active mice.
Article in Journal of biological regulators and homeostatic agents. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Selectively breeding for high voluntary physical activity in female mice does not bestow inherent characteristics that resemble eccentric remodeling of the heart, but the mini-muscle phenotype does.Sports medicine and health science · 2023Article
- The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress.Frontiers in behavioral neuroscience · 2023Article
- Regulation of Voluntary Physical Activity Behavior: A Review of Evidence Involving Dopaminergic Pathways in the Brain.Brain sciences · 2022Review
- Dopaminergic Modulation of Forced Running Performance in Adolescent Rats: Role of Striatal D1 and Extra-striatal D2 Dopamine Receptors.Molecular neurobiology · 2021Article
- The Appetite Suppressant D-norpseudoephedrine (Cathine) ActsFrontiers in neuroscience · 2020Article
- Effects of varying doses of estrogen and caudal pressure on wheel running in orchidectomized male mice.Physiological reports · 2018Article
- Biological/Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC.Medicine and science in sports and exercise · 2018Review
- Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity.The Journal of physiology · 2017Article
- Running from Disease: Molecular Mechanisms Associating Dopamine and Leptin Signaling in the Brain with Physical Inactivity, Obesity, and Type 2 Diabetes.Frontiers in endocrinology · 2017Review
- Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake.Frontiers in behavioral neuroscience · 2016Article
- Differential miRNA expression in inherently high- and low-active inbred mice.Physiological reports · 2015Article
- Wheel running reduces high-fat diet intake, preference and mu-opioid agonist stimulated intake.Behavioural brain research · 2015Article
- Nucleus accumbens neuronal maturation differences in young rats bred for low versus high voluntary running behaviour.The Journal of physiology · 2014Article
- Differential skeletal muscle proteome of high- and low-active mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.Neurobiology of disease · 2014Article
- Differential gene expression in high- and low-active inbred mice.BioMed research international · 2014Article
- Phenotypic and molecular differences between rats selectively bred to voluntarily run high vs. low nightly distances.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Does the difference between physically active and couch potato lie in the dopamine system?International journal of biological sciences · 2010Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The genetic factors involved in the regulation of physical activity are not well understood. The dopamine system has been implicated in the control of voluntary locomotion and wheel running (WR) in mice and is thus a likely candidate as a genetic/biological system important to the regulation of physical activity. This study evaluated the effects of four different dopaminergic acting drugs on WR in differentially active inbred strains of mice. High active C57L/J (n=7, 3 controls, 4 experimental) and low active C3H/HeJ (n=8, 3 controls, 5 experimental) were analyzed for baseline wheel-running indices of distance (km/day), duration (mins/day), and speed (m/min) for 21 days. Experimental mice received increasing doses over four days of each of the following drugs: SKF 81297 (D1 agonist), SCH 23390 (D1 antagonist), GBR 12783 (DAT inhibitor), and AMPT (tyrosine hydroxylase inhibitor). Each drug dose response treatment was separated by three days of recovery (no drug injections). WR indices were monitored during drug treatments and during drug wash-out phases. SKF 81297 significantly reduced (p=0.0004) WR in the C57L/J mice, but did not affect WR in the C3H/HeJ mice. GBR 12783 significantly increased (p=0.0005) WR in C3H/HeJ mice, but did not affect WR in C57L/J mice. Only duration (not overall WR) was significantly reduced in C57L/J mice in response to SCH 23390 (p=0.003) and AMPT (p=0.043). SCH 23390 (p=0.44) and AMPT (p=0.98) did not significantly affect WR in C3H/HeJ mice. These results suggest that genetic differences in dopamine signaling may play a role in the WR response to dopaminergic-acting drugs in inbred strains of mice. The high activity in the C57L/J strain appears most responsive to D1-like receptor acting drugs, while in the C3H/HeJ strain, dopamine re-uptake appears to have an influence on activity level.
Indexed as
Identifiers
22475103PMC4190615W2401569295What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.