ArticleBMC genomics2012
A genome-wide study of two-component signal transduction systems in eight newly sequenced mutans streptococci strains.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- A novel insight into ComE-mediated activation of gene expression inMicrobiology spectrum · 2025Article
- Exploiting Conserved Quorum Sensing Signals in Streptococcus mutans and Streptococcus pneumoniaeMicroorganisms · 2022Article
- A Dual-Functional Orphan Response Regulator Negatively Controls the Differential Transcription of DuplicatemSystems · 2022Article
- The W-Acidic Motif of Histidine Kinase WalK Is Required for Signaling and Transcriptional Regulation inFrontiers in microbiology · 2022Article
- Redox Sensing Modulates the Activity of the ComE Response Regulator of Streptococcus mutans.Journal of bacteriology · 2021Article
- Identification and Characterization of the Two-Component System HK8700-RR8701 of Kocuria rhizophila DC2201.The protein journal · 2019Article
- Quantitative Proteomics Uncovers the Interaction between a Virulence Factor and Mutanobactin Synthetases inmSphere · 2019Article
- Exploring the Genomic Diversity and Cariogenic Differences of Streptococcus mutans Strains Through Pan-Genome and Comparative Genome Analysis.Current microbiology · 2017Article
- Role ofThe Japanese dental science review · 2017Review
- Two-component signal transduction systems in oral bacteria.Journal of oral microbiology · 2017Review
- Chemotaxis without Conventional Two-Component System, Based on Cell Polarity and Aerobic Conditions in Helicity-Switching Swimming ofFrontiers in microbiology · 2017Article
- Membrane Topology and Structural Insights into the Peptide Pheromone Receptor ComD, A Quorum-Sensing Histidine Protein Kinase of Streptococcus mutans.Scientific reports · 2016Article
- Genome-wide analysis of myxobacterial two-component systems: genome relatedness and evolutionary changes.BMC genomics · 2015Article
- Streptococcus mutans copes with heat stress by multiple transcriptional regulons modulating virulence and energy metabolism.Scientific reports · 2015Article
- Molecular analysis of ancient caries.Proceedings. Biological sciences · 2014Article
- A conserved streptococcal membrane protein, LsrS, exhibits a receptor-like function for lantibiotics.Journal of bacteriology · 2014Article
- Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus.Molecular oral microbiology · 2014Article
- Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.Journal of oral microbiology · 2014Article
- Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans.Applied and environmental microbiology · 2013Article
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing.BMC genomics · 2013Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMutans streptococci are a group of gram-positive bacteria including the primary cariogenic dental pathogen Streptococcus mutans and closely related species. Two component systems (TCSs) composed of a signal sensing histidine kinase (HK) and a response regulator (RR) play key roles in pathogenicity, but have not been comparatively studied for these oral bacterial pathogens.
resultsHKs and RRs of 8 newly sequenced mutans streptococci strains, including S. sobrinus DSM20742, S. ratti DSM20564 and six S. mutans strains, were identified and compared to the TCSs of S. mutans UA159 and NN2025, two previously genome sequenced S. mutans strains. Ortholog analysis revealed 18 TCS clusters (HK-RR pairs), 2 orphan HKs and 2 orphan RRs, of which 8 TCS clusters were common to all 10 strains, 6 were absent in one or more strains, and the other 4 were exclusive to individual strains. Further classification of the predicted HKs and RRs revealed interesting aspects of their putative functions. While TCS complements were comparable within the six S. mutans strains, S. sobrinus DSM20742 lacked TCSs possibly involved in acid tolerance and fructan catabolism, and S. ratti DSM20564 possessed 3 unique TCSs but lacked the quorum-sensing related TCS (ComDE). Selected computational predictions were verified by PCR experiments.
conclusionsDifferences in the TCS repertoires of mutans streptococci strains, especially those of S. sobrinus and S. ratti in comparison to S. mutans, imply differences in their response mechanisms for survival in the dynamic oral environment. This genomic level study of TCSs should help in understanding the pathogenicity of these mutans streptococci strains.
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