Evidence map›Paper›PMID 22474632›Full record

ArticleWorld journal of orthopedics2011

Interactions between the immune system and bone.

Patrizia D'Amelio, Giorgia Fornelli, Ilaria Roato, Giovanni Carlo Isaia

Abstract read
In one paragraph

Article in World journal of orthopedics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The role of CD8Frontiers in immunology · 2026
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Effects of anti-tumor necrosis factor α agents on bone.Current opinion in rheumatology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patrizia D'AmelioPatrizia D'Amelio, Giorgia Fornelli, Giovanni Carlo Isaia, Department of Surgical and Medical Disciplines, Section of Gerontology, University of Torino, 10126 Torino, Italy.
Giorgia Fornelli
Ilaria Roato
Giovanni Carlo Isaia

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between the immune system, estrogen deficiency and bone loss is an intriguing and, as yet, unexplained challenge of the past two decades. Here we summarize the evidence that links immune cells, inflammation, cytokine production and osteoclast formation and activity with particular regard to humans.

Indexed as

CytokinesImmune systemMenopauseOsteoclastOsteoporosisT cells

Identifiers

PMID22474632
PMCPMC3302038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.