ArticleWorld journal of orthopedics2011
Role of polyethylene particles in peri-prosthetic osteolysis: A review.
Article in World journal of orthopedics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- The lexicon for periprosthetic bone loss versus osteolysis after cervical disc arthroplasty: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Pooled it
- Are there biological markers for wear or corrosion? A systematic review.Clinical orthopaedics and related research · 2014Pooled it
- Association of polyethylene type with revision and dislocation risk following primary total hip arthroplasty: a population-based cohort study from the Danish Hip Arthroplasty Register.Acta orthopaedica · 2026Article
- A bone histological approach to distinguish periprosthetic joint infection from aseptic osteolysis in revision joint replacement.Bone & joint research · 2026Article
- In Vitro Wear Simulation of a Kinematically Aligned Knee Implant Tilted at an Angle of 8°.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- The effect of hybrid reinforcement of fMWCNT and nHA to UHMWPE mechanical and tribological properties.Scientific reports · 2026Article
- Effects of microplastics on the bones: a comprehensive review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis.Frontiers in cell and developmental biology · 2025Review
- The Measurement of the Oxidative Index of Polyethylene Obtained during Revision Hip Arthroplasty and Assessment of Its Variability Depending on the Degree of Osteolysis, Implantation Time, as Well as the Size and Material of the Utilized Head.Journal of clinical medicine · 2024Article
- Mitigating polyethylene-mediated periprosthetic tissue inflammation through MEDSAH-grafting.PloS one · 2024Article
- Massive Periprosthetic Osteolysis Spreads to the Soft Tissue and Pelvic Region after Primary Total Hip Replacement: A Case Report.Journal of orthopaedic case reports · 2023Article
- Article
- Changes in Metabolism and Mitochondrial Bioenergetics during Polyethylene-Induced Osteoclastogenesis.International journal of molecular sciences · 2022Article
- The Utility of Isotropic 3D Magnetic Resonance Imaging in Assessing Painful Total Ankle Replacements.Foot & ankle orthopaedics · 2022Review
- Article
- The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitro.Bioscience reports · 2021Article
- Evidence for Gender-Specific Bone Loss Mechanisms in Periprosthetic Osteolysis.Journal of clinical medicine · 2019Article
- To cement or not to cement acetabular cups in total hip arthroplasty: a systematic review and re-evaluation.SICOT-J · 2019Article
- Dysregulated expression of antioxidant enzymes in polyethylene particle-induced periprosthetic inflammation and osteolysis.PloS one · 2018Article
- Particle Disease: A Current Review of the Biological Mechanisms in Periprosthetic Osteolysis After Hip Arthroplasty.The open orthopaedics journal · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is convincing evidence that particles produced by the wear of joint prostheses are causal in the peri-prosthetic loss of bone, or osteolysis, which, if it progresses, leads to the phenomenon of aseptic loosening. It is important to fully understand the biology of this bone loss because it threatens prosthesis survival, and loosened implants can result in peri-prosthetic fracture, which is disastrous for the patient and presents a difficult surgical scenario. The focus of this review is the bioactivity of polyethylene (PE) particles, since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface. The review describes the biological consequences of interaction of PE particles with macrophages, osteoclasts and cells of the osteoblast lineage, including osteocytes. It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential non-surgical treatments for osteolysis. In particular, a non-surgical approach is likely to be applicable to implants containing newer, highly cross-linked PEs (HXLPEs), for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs. The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.