ReviewCold Spring Harbor perspectives in medicine2012
The neuropsychological profile of Alzheimer disease.
Review in Cold Spring Harbor perspectives in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 259 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
259 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Virtual reality applications based on instrumental activities of daily living (iADLs) for cognitive intervention in older adults: a systematic review.Journal of neuroengineering and rehabilitation · 2023Pooled it
- Cognitive rehabilitation for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Neuroinflammation: A Common Pathway in Alzheimer's Disease and Epilepsy.Journal of Alzheimer's disease : JAD · 2023Pooled it
- Neuropsychological Assessment and Screening in Heart Failure: a Meta-Analysis and Systematic Review.Neuropsychology review · 2021Pooled it
- APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review.Alzheimer's research & therapy · 2020Pooled it
- Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews.Neuropsychology review · 2020Pooled it
- Cognitive training for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2019Pooled it
- The Effectiveness of GRADIOR: A Neuropsychological Rehabilitation Program for People with Mild Cognitive Impairment and Mild Dementia. Results of a Randomized Controlled Trial After 4 and 12 Months of Treatment.Journal of Alzheimer's disease : JAD · 2022Trial
- A quick test of cognitive speed can predict development of dementia in Parkinson's disease.Scientific reports · 2019Trial
- Associations between cerebral amyloid and changes in cognitive function and falls risk in subcortical ischemic vascular cognitive impairment.BMC geriatrics · 2017Trial
- Study design and results of the Wave VI Add Health Cognitive Assessment, Physical, and Sensory Function (Add CAPS) protocol.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Article
- Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tau T205 phosphorylation modulates engram cell recruitment and remote memory in mice.Nature communications · 2026Article
- Comparative analyses of Alzheimer's disease blood biomarkers and cognitive domains.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive tasks show age-related decline over a 10-year period in a natural aging monkey model, cotton-top tamarins (Saguinus oedipus).Journal of comparative psychology (Washington, D.C. : 1983) · 2026Article
- Low Sensitivity of Neuropsychological Scales Hinder Detection of Potential Benefit of Treatments in Alzheimer's Disease: A Position Paper.European journal of neurology · 2026Review
- Meat Consumption and Cognitive Health by APOE Genotype.JAMA network open · 2026Article
- Characterizing olfaction, anxiety, and depression in subjective cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- The Utility of Speech and Language Analytics for Screening Alzheimer's Disease.Neuro-degenerative diseases · 2026Review
199 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Neuropsychological assessment has featured prominently over the past 30 years in the characterization of dementia associated with Alzheimer disease (AD). Clinical neuropsychological methods have identified the earliest, most definitive cognitive and behavioral symptoms of illness, contributing to the identification, staging, and tracking of disease. With increasing public awareness of dementia, disease detection has moved to earlier stages of illness, at a time when deficits are both behaviorally and pathologically selective. For reasons that are not well understood, early AD pathology frequently targets large-scale neuroanatomical networks for episodic memory before other networks that subserve language, attention, executive functions, and visuospatial abilities. This chapter reviews the pathognomonic neuropsychological features of AD dementia and how these differ from "normal," age-related cognitive decline and from other neurodegenerative diseases that cause dementia, including cortical Lewy body disease, frontotemporal lobar degeneration, and cerebrovascular disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.