ArticleEvidence-based complementary and alternative medicine : eCAM2012
Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Medicinal mushrooms and type 2 diabetes: mechanistic insights, translational evidence, and clinical caveats.Frontiers in nutrition · 2026Review
- Protective effect of Cordyceps sinensis against diabetic kidney disease through promoting proliferation and inhibiting apoptosis of renal proximal tubular cells.BMC complementary medicine and therapies · 2023Article
- Bailing capsule (Frontiers in pharmacology · 2022Article
- Review
- The Effects ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Herbal medicine for sports: a review.Journal of the International Society of Sports Nutrition · 2018Review
- Xiaokening stimulates endothelial nitric oxide release in diabetic rats.Singapore medical journal · 2015Article
- Effects of Cordyceps sinensis on the Expressions of NF-κB and TGF-β1 in Myocardium of Diabetic Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice.Journal of diabetes research · 2015Article
- Ancient records and modern research on the mechanisms of chinese herbal medicines in the treatment of diabetes mellitus.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Cordycepin prevented IL-β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes.International orthopaedics · 2014Article
- Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats.BioMed research international · 2014Article
- Bioactive principles fromJournal of functional foods · 2013Review
- A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in Dong-ChongXiaCao ( Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients.Journal of traditional and complementary medicine · 2013Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is the most common chronic disease in the world, and a wide range of drugs, including Chinese herbs, have been evaluated for the treatment of associated metabolic disorders. This study investigated the potential hypoglycemic and renoprotective effects of an extract from the solid-state fermented mycelium of Cordyceps sinensis (CS). We employed the KK/HIJ diabetic mouse model, in which the mice were provided with a high-fat diet for 8 weeks to induce hyperglycemia, followed by the administration of CS or rosiglitazone for 4 consecutive weeks. Several parameters were evaluated, including changes in body weight, plasma lipid profiles, oral glucose tolerance tests, insulin tolerance tests, and plasma insulin concentrations. Our results show that the CS extract significantly elevated HDL/LDL ratios at 4 weeks and decreased body weight gain at 8 weeks. Interestingly, CS treatment did not lead to obvious improvements in hyperglycemia or resistance to insulin, while in vitro MTT assays indicated that CS protects pancreatic beta cells against the toxic effects of STZ. CS also enhanced renal NKA activity and reduced the accumulation of mesangial matrix and collagen deposition. In conclusion, CS extract can potentially preserve β-cell function and offer renoprotection, which may afford a promising therapy for DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.