SynthesisClinical & developmental immunology2012
A systematic review of the epidemiology, immunopathogenesis, diagnosis, and treatment of pleural TB in HIV-infected patients.
Synthesis in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 19 citations in OpenAlex.
- Tuberculous pleural effusion: integrating thoracic ultrasound and medical thoracoscopy in the diagnosis and management: a pictorial narrative review and an algorithm proposal.Journal of ultrasound · 2026Review
- Artificial intelligence for tuberculosis control: a scoping review of applications in public health.Journal of global health · 2025Article
- Usefulness of Adenosine Deaminase Assay in Diagnosis of Patients with HIV Infection and Pleural Tuberculosis.Medical sciences (Basel, Switzerland) · 2018Article
- Tuberculous Pleural Effusion.Turkish thoracic journal · 2015Review
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh HIV burden countries have experienced a high burden of pleural TB in HIV-infected patients.
objectiveTo review the epidemiology, immunopathogenesis, diagnosis, and treatment of pleural TB in HIV-infected patients.
methodsA literature search from 1950 to June 2011 in MEDLINE was conducted.
resultsTwo-hundred and ninety-nine studies were identified, of which 30 met the inclusion criteria. The immunopathogenesis as denoted by cells and cytokine profiles is distinctly different between HIV and HIV-uninfected pleural TB disease. Adenosine deaminase and interferon gamma are good markers of pleural TB disease even in HIV-infected patients. HIV-uninfected TB suspects with pleural effusions commonly have a low yield of TB organisms however the evidence suggests that in dually infected patients smear and cultures have a higher yield. The Gene Xpert MTB/RIF assay has significant potential to improve the diagnosis of pleural TB in HIV-positive patients.
conclusionsPleural TB in HIV-infected patients has a different immunopathogenesis than HIV-uninfected pleural TB and these findings in part support the differences noted in this systematic review. Research should focus on developing an interferon gamma-based point of care diagnostic test and expansion of the role of Gene Xpert in the diagnosis of pleural TB.
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Registered trials
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