ArticleClinical & developmental immunology2012
Emergence of exhausted B cells in asymptomatic HIV-1-infected patients naïve for HAART is related to reduced immune surveillance.
Article in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Evaluation of TTV replication as a biomarker of immune checkpoint inhibitors efficacy in melanoma patients.PloS one · 2021Trial
- Plasmatic CXCL13 as a biomarker of primary resistance to immunotherapy and impaired peripheral immunity in non-small cell lung cancer.Biomarker research · 2026Article
- Anelloviruses: From General Biology to Their Role as Biomarkers of Immune Competence in HIV Infection.Viruses · 2026Review
- Human antiviral B cell responses: Emerging lessons from hepatitis B and COVID-19.Immunological reviews · 2021Review
- Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease.PloS one · 2020Article
- Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment.Frontiers in cellular and infection microbiology · 2020Article
- Torquetenovirus detection in exosomes enriched vesicles circulating in human plasma samples.Virology journal · 2018Article
- Irreversible phenotypic perturbation and functional impairment of B cells during HIV-1 infection.Frontiers of medicine · 2017Article
- Atypical memory B cells in human chronic infectious diseases: An interim report.Cellular immunology · 2017Review
- Assessing immune aging in HIV-infected patients.Virulence · 2017Review
- Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African Women.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Humoral immune responses to Streptococcus pneumoniae in the setting of HIV-1 infection.Vaccine · 2015Review
- HIV-associated memory B cell perturbations.Vaccine · 2015Review
- Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis.Clinical immunology (Orlando, Fla.) · 2014Article
- Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers.European journal of immunology · 2013Article
- Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Dynamics of memory B-cell populations in blood, lymph nodes, and bone marrow during antiretroviral therapy and envelope boosting in simian immunodeficiency virus SIVmac251-infected rhesus macaques.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations of B cell subpopulations have been described up to date as characterizing advanced stage of HIV-1 infection. However, whether such defects are relevant in subjects with a preserved number of CD4⁺ T cells (>350 cells/μL) is unclear. In a cross-sectional study, we investigated if signs of B cells exhaustion and impaired viral immune surveillance are present in a cohort of 43 asymptomatic HIV-1-infected patients with preserved CD4⁺ T cell counts (>350 cells/μL) and highly active antiretroviral therapy (HAART) untreated. A dramatic expansion of exhausted tissue-like memory B cells (CD10⁻CD21(low)CD27⁻) was observed. B cells alteration was related to an increase in Torque teno virus (TTV) load, used as surrogate marker of immune function. Successfully HAART-treated patients showed normalization of B cell subpopulations frequency and TTV load. These results provide new insights on B cell in HIV-1 infection and show that development of B cell abnormalities precedes CD4⁺ T cell decline.
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