ArticleExperimental diabetes research2012
Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease.
Article in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Lower limb arterial calcification and its clinical relevance with peripheral arterial disease.Frontiers in cardiovascular medicine · 2023Review
- Medial artery calcification in peripheral artery disease.Frontiers in cardiovascular medicine · 2023Review
- Hematopoietic Progenitors and the Bone Marrow Niche Shape the Inflammatory Response and Contribute to Chronic Disease.International journal of molecular sciences · 2022Review
- Mammalian Sirtuins and Their Relevance in Vascular Calcification.Frontiers in pharmacology · 2022Review
- Development and validation of a new method to isolate, expand, and differentiate circulating osteogenic precursor (COP) cells.Bone reports · 2021Article
- Contributions of the Endothelium to Vascular Calcification.Frontiers in cell and developmental biology · 2021Review
- Roles of klotho and stem cells in mediating vascular calcification (Review).Experimental and therapeutic medicine · 2020Review
- miR-34a: A Promising Target for Inflammaging and Age-Related Diseases.International journal of molecular sciences · 2020Article
- Roles of bone-derived hormones in type 2 diabetes and cardiovascular pathophysiology.Molecular metabolism · 2020Review
- When Good Guys Turn Bad: Bone Marrow's and Hematopoietic Stem Cells' Role in the Pathobiology of Diabetic Complications.International journal of molecular sciences · 2020Review
- Cumulative Rheumatic Inflammation Modulates the Bone-Vascular Axis and Risk of Coronary Calcification.Journal of the American Heart Association · 2019Article
- The Key Role of Phosphate on Vascular Calcification.Toxins · 2019Review
- Endothelial Progenitor Cells Biology in Diabetes Mellitus and Peripheral Arterial Disease and their Therapeutic Potential.Stem cell reviews and reports · 2019Review
- Endothelial Progenitor Cells: New Targets for Therapeutics for Inflammatory Conditions With High Cardiovascular Risk.Frontiers in medicine · 2018Review
- High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes.Cardiovascular diabetology · 2017Article
- Is chronic kidney disease-mineral and bone disorder associated with the presence of endothelial progenitor cells with a calcifying phenotype?Clinical kidney journal · 2017Article
- Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients.Clinical kidney journal · 2016Article
- Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction.PloS one · 2016Article
- Mechanisms of ectopic calcification: implications for diabetic vasculopathy.Cardiovascular diagnosis and therapy · 2015Review
- Suitable bone markers assessing bone status in patients with both coronary artery disease and diabetes.Journal of diabetes and metabolic disorders · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) alters circulating progenitor cells relevant for the pathophysiology of coronary artery disease (CAD). While endothelial progenitor cells (EPCs) are reduced, there is no data on procalcific polarization of circulating progenitors, which may contribute to vascular calcification in these patients. In a cohort of 107 subjects with and without DM and CAD, we analyzed the pro-calcific versus endothelial differentiation status of circulating CD34+ progenitor cells. Endothelial commitment was determined by expression of VEGFR-2 (KDR) and pro-calcific polarization by expression of osteocalcin (OC) and bone alkaline phosphatase (BAP). We found that DM patients had significantly higher expression of OC and BAP on circulating CD34+ cells than control subjects, especially in the presence of CAD. In patients with DM and CAD, the ratio of OC/KDR, BAP/KDR, and OC+BAP/KDR was about 3-fold increased than in other groups. EPCs cultured from DM patients with CAD occasionally formed structures highly suggestive of calcified nodules, and the expression of osteogenic markers by EPCs from control subjects was significantly increased in response to the toll-like receptor agonist LPS. In conclusion, circulating progenitor cells of diabetic patients show a phenotypic drift toward a pro-calcific phenotype that may be driven by inflammatory signals.
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