ArticleProceedings of the National Academy of Sciences of the United States of America2012
Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
- CD11a and CD49d enhance the detection of antigen-specific T cells following human vaccination.Vaccine · 2017Trial
- Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination.Science translational medicine · 2016Trial
- The ability of memory CD8 T cell subsets to numerically and functionally recover following whole body irradiation is influenced by their history of cognate antigen exposures.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Modeling T Cell Fate.Annual review of immunology · 2023Review
- Effects of Low-Level Persistent Infection on Maintenance of Immunity by CD4 T Cell Subsets and Th1 Cytokines.Infection and immunity · 2023Article
- The Function of Memory CD8+ T Cells in Immunotherapy for Human Diseases.Immune network · 2023Review
- T Cell Reprogramming Against Cancer.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.Immunological reviews · 2020Review
- Control of memory CD8Molecular immunology · 2020Review
- Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells.The Journal of clinical investigation · 2019Article
- Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection.PLoS pathogens · 2018Article
- Defining Memory CD8 T Cell.Frontiers in immunology · 2018Review
- Maintenance of CD8European journal of immunology · 2017Article
- Article
- Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.PLoS pathogens · 2015Article
- Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection.Journal of virology · 2014Article
- Influence of time and number of antigen encounters on memory CD8 T cell development.Immunologic research · 2014Review
- The longevity of memory CD8 T cell responses after repetitive antigen stimulations.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Infection or successful vaccination results in the formation of long-lived memory CD8 T-cell populations. Despite their numerical stability, memory CD8 T-cell populations are thought to completely turn over through proliferation within a 2- to 3-mo period. Therefore, steady-state memory cell proliferation must be balanced by a precisely regulated and equivalent death rate. However, the mechanisms regulating this balancing process remain completely undefined. Herein, we provide evidence for "death-intermediate memory cells" (T(DIM)) within memory CD8 T-cell populations generated by infection. Importantly, CD62L(Lo)/CD27(Lo) T(DIM)s are functionally characterized by an inability to produce cytokines, the failure to internalize T-cell receptor following antigenic stimulation, and signatures of apoptotic death. Furthermore, we demonstrate that, mechanistically, T(DIM) are directly generated from dividing "central memory" T-cell populations undergoing memory turnover in vivo. Collectively, these results demonstrate that as central memory CD8 T cells proliferate, they continuously generate a population of CD8 T cells that are nonfunctional and apoptotic; thus, our data support a model wherein division-linked generation of T(DIM) contributes to numerically stable CD8 T-cell memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.