ArticleProceedings of the National Academy of Sciences of the United States of America2012
Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Regulation of autophagy by the p53 family and the implications for cancer therapies.Discover oncology · 2026Review
- Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree.Cell death & disease · 2023Article
- Structural diversity of p63 and p73 isoforms.Cell death and differentiation · 2022Review
- Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy.Cancers · 2021Review
- Pirh2, an E3 ligase, regulates the AIP4-p73 regulatory pathway by modulating AIP4 expression and ubiquitination.Carcinogenesis · 2021Article
- Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates.Nature communications · 2021Article
- MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73.Cell death & disease · 2020Article
- Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation.International journal of molecular sciences · 2019Review
- Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-SpecificallyBiochemistry · 2019Article
- Defining TP53 pioneering capabilities with competitive nucleosome binding assays.Genome research · 2019Article
- Modulation of Hoogsteen dynamics on DNA recognition.Nature communications · 2018Article
- Article
- Robust IR-based detection of stable and fractionally populated G-CFEBS letters · 2017Article
- ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function.Oncotarget · 2016Article
- Functional interplay between MDM2, p63/p73 and mutant p53.Oncogene · 2015Article
- Whole-genome cartography of p53 response elements ranked on transactivation potential.BMC genomics · 2015Article
- New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.Nucleic acids research · 2015Review
- YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues.Molecular and cellular biology · 2015Article
- Structure and apoptotic function of p73.BMB reports · 2015Review
- Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay.PloS one · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The transcription factor p73 triggers developmental pathways and overlaps stress-induced p53 transcriptional pathways. How p53-family response elements determine and regulate transcriptional specificity remains an unsolved problem. In this work, we have determined the first crystal structures of p73 DNA-binding domain tetramer bound to response elements with spacers of different length. The structure and function of the adaptable tetramer are determined by the distance between two half-sites. The structures with zero and one base-pair spacers show compact p73 DNA-binding domain tetramers with large tetramerization interfaces; a two base-pair spacer results in DNA unwinding and a smaller tetramerization interface, whereas a four base-pair spacer hinders tetramerization. Functionally, p73 is more sensitive to spacer length than p53, with one base-pair spacer reducing 90% of transactivation activity and longer spacers reducing transactivation to basal levels. Our results establish the quaternary structure of the p73 DNA-binding domain required as a scaffold to promote transactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.