ArticleDiabetes care2012
Association of high pulse pressure with proteinuria in subjects with diabetes, prediabetes, or normal glucose tolerance in a large Japanese general population sample.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Reduction of mean arterial pressure and proteinuria by the effect of ACEIs (Lisinopril) in Kurdish hypertensive patients in Hawler City.Global journal of health science · 2012Trial
- High remnant cholesterol as a risk factor for developing chronic kidney disease in patients with prediabetes and type 2 diabetes: a cross-sectional study of a US population.Acta diabetologica · 2024Article
- Hemoglobin Glycation Index: A Novel Risk Factor for Incident Chronic Kidney Disease in an Apparently Healthy Population.The Journal of clinical endocrinology and metabolism · 2024Article
- Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community-Based Study.Journal of the American Heart Association · 2023Article
- Association between height loss and mortality in the general population.Scientific reports · 2023Article
- Urinary epidermal growth factor reflects vascular health in boys with either obesity or type 1 diabetes. A role for renin, or beyond?PloS one · 2023Article
- Health-related behavioral changes and incidence of chronic kidney disease: The Japan Specific Health Checkups (J-SHC) Study.Scientific reports · 2022Article
- Hepatic Steatosis and High-Normal Fasting Glucose as Risk Factors for Incident Prediabetes.Journal of the Endocrine Society · 2022Article
- Association of remnant cholesterol with chronic kidney disease in middle-aged and elderly Chinese: a population-based study.Acta diabetologica · 2021Article
- Impact of Metabolic Syndrome on the Mortality Rate among Participants in a Specific Health Check and Guidance Program in Japan.Internal medicine (Tokyo, Japan) · 2020Article
- Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes.Journal of the American Heart Association · 2019Article
- Pulse Pressure and Diabetic Eye Disease.Journal of the American Heart Association · 2019Article
- Article
- Dipstick proteinuria and all-cause mortality among the general population.Clinical and experimental nephrology · 2018Article
- Mortality risk among screened subjects of the specific health check and guidance program in Japan 2008-2012.Clinical and experimental nephrology · 2017Article
- Significance of estimated glomerular filtration rate in predicting brain or heart attacks in obese and non-obese populations.Clinical and experimental nephrology · 2015Article
- Impact of population aging on trends in diabetes prevalence: A meta-regression analysis of 160,000 Japanese adults.Journal of diabetes investigation · 2015Article
- Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease.International journal of medical sciences · 2015Article
- The importance of weight management in type 2 diabetes mellitus.International journal of clinical practice · 2014Article
- U-shaped association between body mass index and proteinuria in a large Japanese general population sample.Clinical and experimental nephrology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether there is a difference in the association between high pulse pressure and proteinuria, independent of other blood pressure (BP) indices, such as systolic or diastolic BP, among subjects with diabetes, prediabetes, or normal glucose tolerance. RESEARCH DESIGN AND
methodsUsing a nationwide health checkup database of 228,778 Japanese aged ≥ 20 years (mean 63.2 years; 39.3% men; none had pre-existing cardiovascular disease), we examined the association between high pulse pressure, defined as the highest quintile of pulse pressure (≥ 63 mmHg, n = 40,511), and proteinuria (≥ 1+ on dipstick, n = 12,090) separately in subjects with diabetes (n = 27,913), prediabetes (n = 100,214), and normal glucose tolerance (n = 100,651).
resultsThe prevalence of proteinuria was different among subjects with diabetes, prediabetes, and normal glucose tolerance (11.3 vs. 5.0 vs. 3.9%, respectively; P < 0.001). In subjects with diabetes, but not those with prediabetes or normal glucose tolerance, high pulse pressure was associated with proteinuria independently of significant covariates, including systolic BP (odds ratio 1.15 [95% CI 1.04-1.28]) or diastolic or mean BP (all P < 0.01). In patients with diabetes, a +1 SD increase of pulse pressure (+13 mmHg) was associated with proteinuria, even after adjustment for systolic BP (1.07 [1.00-1.13]) or diastolic or mean BP (all P < 0.05).
conclusionsAmong the Japanese general population, there was a significant difference in the association between high pulse pressure and proteinuria among subjects with diabetes, prediabetes, and normal glucose tolerance. Only in diabetes was high pulse pressure associated with proteinuria independent of systolic, diastolic, or mean BP levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.