ArticleCold Spring Harbor perspectives in biology2012
The synchrony and cyclicity of developmental events.
Article in Cold Spring Harbor perspectives in biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Embryology of the Abdominal Wall and Associated Malformations-A Review.Frontiers in surgery · 2022Review
- Molecular and Mechanical Cues for Somite Periodicity.Frontiers in cell and developmental biology · 2021Review
- Constraints on somite formation in developing embryos.Journal of the Royal Society, Interface · 2019Article
- Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation.Development (Cambridge, England) · 2018Article
- Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish.Development (Cambridge, England) · 2016Article
- Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations.Papers in physics · 2014Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Many of the morphogenetic processes that occur during development in the mouse are based on cyclic events with defined time intervals, as exemplified by somitogenesis (every 2 h), hair cycles (every 25 d), and spermatogenesis (every 35 d). Among these events, somitogenesis is the most dynamic morphogenetic mechanism showing clear cyclicity during embryogenesis and is therefore a good system with which to review the synchronous and cyclic characteristics of developmental pathways. The metameric properties of the somites underpin the segmental properties along the anterior-posterior (AP) axis of the body. The periodicity of somites is controlled by the so-called segmentation clock operating in the presomitic mesoderm (PSM). This tissue contains the somite precursor cells that exist only during embryonic development. Both theoretical and experimental approaches have contributed to the understanding of the mechanism of somite segmentation. This article focuses on how the segmentation clock functions to organize the collective behavior of cells and how this information is translated into the spatial patterning of segmental somites. The interplay between signaling molecules that provides positional information and the transcription factors that respond to such positional cues are critical to the role of the segmentation clock and are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.