ArticleMolecular and cellular biology2012
POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Modulation of RNA stability regulates gene expression in two opposite ways: through buffering of RNA levels upon global perturbations and by supporting adapted differential expression.Nucleic acids research · 2022Article
- RNA Pol IV induces antagonistic parent-of-origin effects on Arabidopsis endosperm.PLoS biology · 2022Article
- Review
- The role of H3K36 methylation and associated methyltransferases in chromosome-specific gene regulation.Science advances · 2021Article
- Establishment and evolution of heterochromatin.Annals of the New York Academy of Sciences · 2020Review
- Article
- The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence.BMC biology · 2019Article
- Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.Nature communications · 2019Article
- Molecular and genetic organization of bands and interbands in the dot chromosome of Drosophila melanogaster.Chromosoma · 2019Article
- RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.PLoS genetics · 2018Article
- TheGenetics · 2018Article
- The X-linked 1.688 Satellite inGenetics · 2018Article
- Proximity ligation assays of protein and RNA interactions in the male-specific lethal complex on Drosophila melanogaster polytene chromosomes.Chromosoma · 2015Article
- Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in Drosophila.PLoS genetics · 2015Article
- Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions.PLoS genetics · 2014Article
- Transcriptional control of a whole chromosome: emerging models for dosage compensation.Nature structural & molecular biology · 2014Review
- Male X-linked genes in Drosophila melanogaster are compensated independently of the Male-Specific Lethal complex.Epigenetics & chromatin · 2013Article
- Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster.G3 (Bethesda, Md.) · 2013Article
- The variant histone H2A.V of Drosophila--three roles, two guises.Chromosoma · 2013Review
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila, two chromosome-wide compensatory systems have been characterized: the dosage compensation system that acts on the male X chromosome and the chromosome-specific regulation of genes located on the heterochromatic fourth chromosome. Dosage compensation in Drosophila is accomplished by hypertranscription of the single male X chromosome mediated by the male-specific lethal (MSL) complex. The mechanism of this compensation is suggested to involve enhanced transcriptional elongation mediated by the MSL complex, while the mechanism of compensation mediated by the painting of fourth (POF) protein on the fourth chromosome has remained elusive. Here, we show that POF binds to nascent RNA, and this binding is associated with increased transcription output from chromosome 4. We also show that genes located in heterochromatic regions spend less time in transition from the site of transcription to the nuclear envelope. These results provide useful insights into the means by which genes in heterochromatic regions can overcome the repressive influence of their hostile environment.
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