Trial reportThe Journal of physiology2012
Cerebellar modulation of human associative plasticity.
Trial report in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07014384 (A Randomized, Sham-controlled Study of Cerebellar Transcranial Direct Current Stimulation), which is not on this map. Cited by 86 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Sham-controlled Study of Cerebellar Transcranial Direct Current Stimulation (tDCS) and Its Effects on the Neurophysiological Properties of the Sensorimotor Network and Motor Symptom Severity in Patients With Isolated Cervical Dystonia (CD)
Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Targeting the Human Cerebellum with Transcranial Direct Current Stimulation to Modulate Behavior: a Meta-Analysis.Cerebellum (London, England) · 2018Pooled it
- Inhibitory Circuits of the Sensorimotor Network are Not Modulated By Cerebellar Transcranial Direct Current Stimulation in Isolated Cervical Dystonia.Cerebellum (London, England) · 2026Trial
- Online polarity-dependent effects of cerebellar transcranial direct current stimulation on motor speed and fine manual dexterity. A randomized controlled trial.Saudi medical journal · 2020Trial
- What Do We Know About the Influence of the Cerebellum on Walking Ability? Promising Findings from Transcranial Alternating Current Stimulation.Cerebellum (London, England) · 2017Trial
- Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation.PloS one · 2015Trial
- Two distinct interneuron circuits in human motor cortex are linked to different subsets of physiological and behavioral plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Deleterious effects of a low amount of ethanol on LTP-like plasticity in human cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Modulating human procedural learning by cerebellar transcranial direct current stimulation.Cerebellum (London, England) · 2013Trial
- Defective cerebellar control of cortical plasticity in writer's cramp.Brain : a journal of neurology · 2013Trial
- Priming pharyngeal motor cortex by repeated paired associative stimulation: implications for dysphagia neurorehabilitation.Neurorehabilitation and neural repair · 2013Trial
- Timing-dependent inhibitory effects of peripheral somatosensory inputs on the primary motor cortex: A transcranial magnetic stimulation-electroencephalography study.Neuroimage. Reports · 2026Article
- Pulse waveform and current direction alter network-level TMS-induced functional connectivity: Evidence from TMS-EEG.NeuroImage · 2026Article
- [Research on the effect of transcranial direct current stimulation regulation of different targets on working memory based on electroencephalography].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Cerebellar Paired Associative Stimulation Enhances Motor Learning and Modulates Cerebellar Output in a Timing- and Task-Dependent Manner.Cerebellum (London, England) · 2026Article
- Timing- and frequency-specific effects of dentate nucleus deep brain stimulation on somatosensory-evoked potentials in people with poststroke hemiparesis.Journal of neurophysiology · 2025Article
- Structure-function association of the cerebellar motor network is altered in isolated cervical dystonia.Journal of neurology · 2025Article
- Electroencephalographic responses before, during, and after upper limb paired associative stimulation.Data in brief · 2025Article
- Neurophysiological markers of motor compensatory mechanisms in early Parkinson's disease.Brain : a journal of neurology · 2024Article
- Cerebellar Direct Current Stimulation Reveals the Causal Role of the Cerebellum in Temporal Prediction.Cerebellum (London, England) · 2024Article
- Cerebellar Non-Invasive Brain Stimulation: A Frontier in Chronic Pain Therapy.Journal of personalized medicine · 2024Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paired associative stimulation (PAS) is a method commonly used in human studies of motor cortex synaptic plasticity. It involves repeated pairs of electrical stimuli to the median nerve and transcranial magnetic stimulation (TMS) of the motor cortex. If the interval between peripheral and TMS stimulation is around 21–25 ms, corticospinal excitability is increased for the following 30–60 min via a long term potentiation (LTP)-like effect within the primary motor cortex. Previous work has shown that PAS depends on the present and previous levels of activity in cortex, and that it can be modified by motor learning or attention. Here we show that simultaneous transcranial direct current stimulation (TDCS; 2 mA) over the cerebellum can abolish the PAS effect entirely. Surprisingly, the effect is seen when the PAS interval is 25 ms but not when it is 21.5 ms. There are two implications from this work. First, the cerebellum influences PAS effects in motor cortex; second, LTP-like effects of PAS have at least two different mechanisms. The results are relevant for interpretation of pathological changes that have been reported in response to PAS in people with movement disorders and to changes in healthy individuals following exercise or other interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.