ArticleThe Journal of physiology2012
How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes.Scientific reports · 2022Trial
- Resolving Artifacts in Voltage-Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- In silico analysis of ventricular action potential with a current-voltage-time representation: Thresholds, membrane resistance, repolarization reserve.Physiological reports · 2024Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Cell-specific models of hiPSC-CMs developed by the gradient-based parameter optimization method fitting two different action potential waveforms.Scientific reports · 2024Article
- Models of the cardiac L-type calcium current: A quantitative review.WIREs mechanisms of disease · 2023Review
- Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar.PLoS computational biology · 2022Article
- Bifurcations and Proarrhythmic Behaviors in Cardiac Electrical Excitations.Biomolecules · 2022Review
- Pacemaking function of two simplified cell models.PloS one · 2022Article
- ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Review
- IonoBiology: The functional dynamics of the intracellular metallome, with lessons from bacteria.Cell systems · 2021Review
- Article
- Calibration of ionic and cellular cardiac electrophysiology models.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Considering discrepancy when calibrating a mechanistic electrophysiology model.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Data-Driven Uncertainty Quantification for Cardiac Electrophysiological Models: Impact of Physiological Variability on Action Potential and Spiral Wave Dynamics.Frontiers in physiology · 2020Article
- An Understandable, Extensible, and Reusable Implementation of the Hodgkin-Huxley Equations Using Modelica.Frontiers in physiology · 2020Article
- Reproducible model development in the cardiac electrophysiology Web Lab.Progress in biophysics and molecular biology · 2018Article
- Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut.The Journal of physiology · 2018Review
- A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research.Frontiers in physiology · 2018Review
- Validation and Trustworthiness of Multiscale Models of Cardiac Electrophysiology.Frontiers in physiology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early modelling of cardiac cells (1960-1980) was based on extensions of the Hodgkin-Huxley nerve axon equations with additional channels incorporated, but after 1980 it became clear that processes other than ion channel gating were also critical in generating electrical activity. This article reviews the development of models representing almost all cell types in the heart, many different species, and the software tools that have been created to facilitate the cardiac Physiome Project.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.