Evidence map›Paper›PMID 22473660›Full record

ArticleMagnetic resonance in medicine2013

Fast gated EPR imaging of the beating heart: spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.

Zhiyu Chen, Levy A Reyes, David H Johnson, Murugesan Velayutham, Changjun Yang, Alexandre Samouilov, Jay L Zweier

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. High fidelity triangular sweep of the magnetic field for millisecond scan EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021
    Article
  2. Article
  3. Article
  4. Article
  5. Accelerated dynamic EPR imaging using fast acquisition and compressive recovery.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhiyu ChenCenter for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA.
Levy A Reyes
David H Johnson
Murugesan Velayutham
Changjun Yang
Alexandre Samouilov
Jay L Zweier

Funding

OXYGEN RADICALS AND NITRIC OXIDE IN POSTISCHEMIC INJURYR01HL063744 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2000 to 2009
$5.2M
MEASURE OF FREE RADICAL GENERATION IN HEARTR01HL038324 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 1992 to 2010
$3.5M
Proton Electron Double Resonance Imaging (PEDRI) of Free RadicalsR01EB004900 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2005 to 2008
$3.4M
In Vivo EPR/NMR Co-Imaging of Free RadicalsR01EB000890 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2002 to 2005
$2.9M
Optimization of EPR Acquisitions and Post-processingF32EB012932 · NIBIB · OHIO STATE UNIVERSITY · PI JOHNSON, DAVID H. · 2011 to 2012
$106k
MEASUREMENT OF FREE RADICAL GENERATION IN THE HEARTR29HL038324 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ZWEIER, JAY LOUIS · 1987 to 1991
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NHLBI NIH HHS HL38324NHLBI NIH HHS R01 HL038324NHLBI NIH HHS R01 HL063744NIBIB NIH HHS EB0890NIBIB NIH HHS EB4900NIBIB NIH HHS F32 EB012932NIBIB NIH HHS R01 EB000890NIBIB NIH HHS R01 EB004900
6 · The paper itself

Abstract

In vivo or ex vivo electron paramagnetic resonance imaging (EPRI) is a powerful technique for determining the spatial distribution of free radicals and other paramagnetic species in living organs and tissues. However, applications of EPRI have been limited by long projection acquisition times and the consequent fact that rapid gated EPRI was not possible. Hence in vivo EPRI typically provided only time-averaged information. In order to achieve direct gated EPRI, a fast EPR acquisition scheme was developed to decrease EPR projection acquisition time down to 10-20 ms, along with corresponding software and instrumentation to achieve fast gated EPRI of the isolated beating heart with submillimeter spatial resolution in as little as 2-3 min. Reconstructed images display temporal and spatial variations of the free-radical distribution, anatomical structure, and contractile function within the rat heart during the cardiac cycle.

Indexed as

AnimalsCardiac-Gated Imaging TechniquesElectron Spin Resonance SpectroscopyFree RadicalsImaging, Three-DimensionalIn Vitro TechniquesMagnetic Resonance ImagingMyocardial ContractionMyocardiumRatsRats, Sprague-DawleyReproducibility of ResultsSensitivity and SpecificityFree Radicals

Identifiers

PMID22473660
PMCPMC3394889

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.