ArticleMagnetic resonance in medicine2013
Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS.
Article in Magnetic resonance in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone.Hypertension (Dallas, Tex. : 1979) · 2023Trial
- The effect of exercise on intramyocellular acetylcarnitine (AcCtn) concentration in adult growth hormone deficiency (GHD).Scientific reports · 2019Trial
- Multiparametric quantitative magnetic resonance imaging of skeletal muscle in CKD.American journal of physiology. Renal physiology · 2025Article
- Combining Dipole and Loop Coil Elements for 7 T Magnetic Resonance Studies of the Human Calf Muscle.Sensors (Basel, Switzerland) · 2024Article
- Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleavedScientific reports · 2024Article
- A systematic review of the relationship between muscle oxygen dynamics and energy rich phosphates. Can NIRS help?BMC sports science, medicine & rehabilitation · 2024Article
- Postcontraction [acetylcarnitine] reflects interindividual variation in skeletal muscle ATP production patterns in vivo.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Investigating the Underlying Mechanisms ofMolecules (Basel, Switzerland) · 2023Article
- Xiaoyi Yusi decoction improves fertilization and embryo transfer outcomes in patients with endometriosis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- HyperpolarizedRadiology · 2021Article
- Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations.NMR in biomedicine · 2021Review
- Dose-Effect/Toxicity of Bupleuri Radix on Chronic Unpredictable Mild Stress and Normal Rats Based on Liver Metabolomics.Frontiers in pharmacology · 2021Article
- Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy.Muscle & nerve · 2018Article
- Assessment of Lipid and Metabolite Changes in Obese Calf Muscle Using Multi-Echo Echo-planar Correlated Spectroscopic Imaging.Scientific reports · 2017Article
- Detection and Alterations of Acetylcarnitine in Human Skeletal Muscles by 1H MRS at 7 T.Investigative radiology · 2017Article
- Deciphering the Differential Effective and Toxic Responses of Bupleuri Radix following the Induction of Chronic Unpredictable Mild Stress and in Healthy Rats Based on Serum Metabolic Profiles.Frontiers in pharmacology · 2017Article
- Amplification of the effects of magnetization exchange by (31) P band inversion for measuring adenosine triphosphate synthesis rates in human skeletal muscle.Magnetic resonance in medicine · 2015Article
- Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.Cell metabolism · 2015Article
- Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.The Journal of clinical investigation · 2014Article
- A pilot validation of multi-echo based echo-planar correlated spectroscopic imaging in human calf muscles.NMR in biomedicine · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
A trimethylamine (TMA) moiety is present in carnitine and acetylcarnitine, and both molecules play critical roles in muscle metabolism. At 7 T, the chemical shift dispersion was sufficient to routinely resolve the TMA signals from carnitine at 3.20 and from acetylcarnitine at 3.17 ppm in the (1)H-MRS (Magnetic Resonance Spectroscopy) of human soleus muscle with a temporal resolution of about 2 min. In healthy, sedentary adults, the concentration of acetylcarnitine increased nearly 10-fold, to 4.1 ± 1.0 mmol/kg, in soleus muscle after 5 min of calf-raise exercise and recovered to a baseline concentration of 0.5 ± 0.3 mmol/kg. While the half-time for decay of acetylcarnitine was the same whether measured from the TMA signal (18.8 ± 5.6 min) or measured from the methyl signal (19.4 ± 6.1 min), the detection of acetylcarnitine by its TMA signal in soleus has the advantage of higher sensitivity and without overlapping from lipid signals. Although the activity of carnitine acetyltransferase is sufficient to allow equilibrium between carnitine and coenzyme-A pools, the exchange in TMA signal between carnitine and acetylcarnitine is slow in soleus following exercise on 7T (1)H-NMR time scale. The TMA signal provides a simple and direct measure of the relative amounts of carnitine and acetylcarnitine.
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