Evidence map›Paper›PMID 22473358›Full record

ArticleChemical communications (Cambridge, England)2012

Photocaged permeability: a new strategy for controlled drug release.

M Michael Dcona, Deboleena Mitra, Rachel W Goehe, David A Gewirtz, Deborah A Lebman, Matthew C T Hartman

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. A Photocleavable Contrast Agent for Light-Responsive MRI.Pharmaceuticals (Basel, Switzerland) · 2020
    Article
  5. Review
  6. Review
  7. Photo-controlled delivery of a potent analogue of doxorubicin.Chemical communications (Cambridge, England) · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Light induced drug release from a folic acid-drug conjugate.Bioorganic & medicinal chemistry letters · 2017
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M Michael DconaDepartment of Chemistry, Virginia Commonwealth University (VCU), 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA.
Deboleena Mitra
Rachel W Goehe
David A Gewirtz
Deborah A Lebman
Matthew C T Hartman
Children's Hospital of Richmond at VCU · USVirginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
VCU Neuroscience Center Core GrantP30NS047463 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI POVLISHOCK, JOHN T · 2003 to 2013
$5.0M
NCI NIH HHS P30 CA016059NCI NIH HHS P30CA16059NINDS NIH HHS 5P30NS047463NINDS NIH HHS P30 NS047463
6 · The paper itself

Abstract

Light is used to release a drug from a cell impermeable small molecule, uncloaking its cytotoxic effect on cancer cells.

Indexed as

Delayed-Action PreparationsLightModels, BiologicalAntineoplastic AgentsCell LineDoxorubicinFlow CytometryHumansMolecular StructureNaphthalenesulfonatesPermeabilityPharmaceutical Preparations5-((2-aminoethyl)amino)naphthalene-1-sulfonic acidAntineoplastic AgentsDelayed-Action PreparationsDoxorubicinNaphthalenesulfonatesPharmaceutical Preparations

Identifiers

PMID22473358
PMCPMC3500139
OpenAlexW2164661659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.