Evidence map›Paper›PMID 22473297›Full record

ReviewEMBO reports2012

The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells.

Bong Ihn Koh, Yibin Kang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EMBO reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
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  14. Activated CD8Nature communications · 2018
    Article
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  20. De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bong Ihn KohDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Yibin Kang

Funding

Metadherin in Metastasis and Chemoresistance of Breast CancerR01CA134519 · NCI · PRINCETON UNIVERSITY · PI KANG, YIBIN · 2008 to 2012
$1.6M
The Role of miRNAs in Epithelial-Mesenchymal Transition and MetastasisR01CA141062 · NCI · PRINCETON UNIVERSITY · PI KANG, YIBIN · 2010 to 2014
$1.6M
NCI NIH HHS R01 CA134519NCI NIH HHS R01CA134519NCI NIH HHS R01 CA141062NCI NIH HHS R01CA141062
6 · The paper itself

Abstract

Several bone marrow-derived cells have been shown to promote tumour growth and progression. These cells can home to the primary tumour and become active components of the tumour microenvironment. Recent studies have also identified bone marrow-derived cells—such as mesenchymal stem cells and regulatory T cells—as contributors to cancer metastasis. The innate versatility of these cells provides diverse functional aid to promote malignancy, ranging from structural support to signal-mediated suppression of the host immune response. Here, we review the role of mesenchymal stem cells and regulatory T cells in cancer metastasis. A better understanding of the bipolar nature of these bone marrow-derived cells in physiological and malignant contexts could pave the way for new therapeutics against metastatic disease.

Indexed as

AnimalsBone Marrow CellsHumansMesenchymal Stem CellsNeoplasm MetastasisT-Lymphocytes, Regulatory

Identifiers

PMID22473297
PMCPMC3343352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.