Evidence map›Paper›PMID 22473079›Full record

ReviewNature reviews. Cardiology2012

Stress and cardiovascular disease.

Andrew Steptoe, Mika Kivimäki

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 602 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
602citing papers in PubMed, 8 pooled it
41.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02972554 phase4completednot on this mapstarted 2016, after this paper: background citation

Beta-Blockers and Inflammatory Responses to Acute Psychosocial Stress

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2016 to 2017Enrolled92ConditionsStress, Psychological, Inflammation, Cortisol, Sympathetic Nervous SystemArmsPropanolol hydrochloride, Placebo
NCT05560893 nacompletednot on this mapstarted 2022, after this paper: background citation

El Corazon de La Comunidad Study - The Purpose of This Research Study is to Develop, Implement, and Evaluate a Community-based Approach to Bolstering the Health and Efficacy of Community Service Providers

TypeinterventionalSponsorUniversity of California, IrvineRan2022 to 2024Enrolled84ConditionsHeart Rate VariabilityArmsRelational Savoring Intervention
NCT07622589 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

NeuroFinance Human Stress Trial During Financial and Informational Volatility (NFHST)

Typeobservational_patient_registrySponsorTruway Health, Inc.Ran2026 to 2029Enrolled2,500ConditionsPsychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System DysfunctionArmsWearable Physiologic Monitoring Platform
3 · Its place in the literature

Who cites it

602 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,273 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Associations of Urban Built Environment with Cardiovascular Risks and Mortality: a Systematic Review.Journal of urban health : bulletin of the New York Academy of Medicine · 2023
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

542 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrew SteptoeDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK. a.steptoe@ucl.ac.uk
Mika Kivimäki
University College London · GB

Funding

British Heart Foundation RG/07/008/23674British Heart Foundation RG/10/005/28296Medical Research Council G0100222Medical Research Council G0902037Medical Research Council G19/35Medical Research Council G8802774
6 · The paper itself

Abstract

The physiological reaction to psychological stress, involving the hypothalamic-pituitary-adrenocortical and sympatho-adrenomedullary axes, is well characterized, but its link to cardiovascular disease risk is not well understood. Epidemiological data show that chronic stress predicts the occurrence of coronary heart disease (CHD). Employees who experience work-related stress and individuals who are socially isolated or lonely have an increased risk of a first CHD event. In addition, short-term emotional stress can act as a trigger of cardiac events among individuals with advanced atherosclerosis. A stress-specific coronary syndrome, known as transient left ventricular apical ballooning cardiomyopathy or stress (Takotsubo) cardiomyopathy, also exists. Among patients with CHD, acute psychological stress has been shown to induce transient myocardial ischemia and long-term stress can increase the risk of recurrent CHD events and mortality. Applications of the 'stress concept' (the understanding of stress as a risk factor and the use of stress management) in the clinical settings have been relatively limited, although the importance of stress management is highlighted in European guidelines for cardiovascular disease prevention.

Indexed as

Mental HealthAnimalsCardiovascular DiseasesChronic DiseaseHumansPractice Guidelines as TopicPrognosisRisk AssessmentRisk FactorsStress, Psychological

Identifiers

PMID22473079
OpenAlexW1987538872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.