ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Molecular signaling and clinical implications in the human aging-cancer cycle.Seminars in cancer biology · 2024Review
- Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer.Nature communications · 2024Article
- A novel perspective suggesting high sustained energy expenditure may be net protective against cancer.Evolution, medicine, and public health · 2022Article
- Two-Step Senescence-Focused Cancer Therapies.Trends in cell biology · 2018Review
- Shortcomings of the immunological model of carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cancer and aging: Epidemiology and methodological challenges.Acta oncologica (Stockholm, Sweden) · 2016Article
- Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.Annals of epidemiology · 2015Article
- Age and cancer risk: a potentially modifiable relationship.American journal of preventive medicine · 2014Article
- How ageing processes influence cancer.Nature reviews. Cancer · 2013Review
- The genetics of age-related health outcomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAnimal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.
methodsA total of 4,354 twin pairs born 1900-1918 in Denmark were followed for mortality in the Danish Civil Registration System through 2008 and for cancer incidence in the period 1943-2008 through the Danish Cancer Registry.
resultsThe 8,139 twins who provided risk time for cancer occurrence entered the study between ages 24 and 43 (mean 33 years), and each participant was followed up to death, emigration, or at least 90 years of age. The total follow-up time was 353,410 person-years and, 2,524 cancers were diagnosed. A negative association between age at death of a twin and cancer incidence in the cotwin was found in the overall analyses as well as in the subanalysis stratified on sex, zygosity, and random selection of one twin from each twin pair.
conclusionsThis study did not find evidence of a cancer-longevity trade-off in humans. On the contrary, it suggested that longevity in one twin is associated with lower cancer incidence in the cotwin, indicating familial factors associated with both low cancer occurrence and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.