Evidence map›Paper›PMID 22472880›Full record

ArticleBritish journal of cancer2012

MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.

A M J Langers, H W Verspaget, L J A C Hawinkels, F J G M Kubben, W van Duijn, J J van der Reijden, J C H Hardwick, D W Hommes, C F M Sier

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  3. Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
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  18. Extracellular Matrix Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

A M J LangersDepartment of Gastroenterology-Hepatology, Leiden University Medical Centre, The Netherlands. a.m.j.langers@lumc.nl
H W Verspaget
L J A C Hawinkels
F J G M Kubben
W van Duijn
J J van der Reijden
J C H Hardwick
D W Hommes
C F M Sier
Leiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUpregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.

methodsWe assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease.

resultsA high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (-1306C>T) and MMP-9 (-1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification.

conclusionMMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients.

Indexed as

AgedColorectal NeoplasmsEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mucous MembraneNeoplasm StagingPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotidePrognosisProspective StudiesRetrospective StudiesMatrix Metalloproteinase 2Matrix Metalloproteinase 9

Identifiers

PMID22472880
PMCPMC3341861
OpenAlexW1964002803

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.