ArticleMucosal immunology2012
Neuroimmune semaphorin 4A downregulates the severity of allergic response.
Article in Mucosal immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Semaphorins and Their Role in Neuropathic Pain.Life (Basel, Switzerland) · 2026Review
- Diverse Roles of Semaphorins on T Cell Activation, Differentiation, Migration, and Effector Functions.Cells · 2026Review
- Article
- Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins.Frontiers in immunology · 2023Article
- Identifying Function Determining Residues in Neuroimmune Semaphorin 4A.International journal of molecular sciences · 2022Article
- Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner.International journal of molecular sciences · 2020Article
- Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1.ImmunoHorizons · 2019Article
- Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?International journal of molecular sciences · 2018Review
- Neuroimmune semaphorins as costimulatory molecules and beyond.Molecular medicine (Cambridge, Mass.) · 2018Review
- Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4.Nature communications · 2018Article
- Downregulation of semaphorin 3E promotes hallmarks of experimental chronic allergic asthma.Oncotarget · 2017Article
- Semaphorins 4A and 4D in chronic inflammatory diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A.Oncotarget · 2016Article
- Transmembrane semaphorins: Multimodal signaling cues in development and cancer.Cell adhesion & migration · 2016Review
- The role of Sema4A in angiogenesis, immune responses, carcinogenesis, and retinal systems.Cell adhesion & migration · 2016Review
- Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis.Arthritis research & therapy · 2015Article
- The Involvement of Immune Semaphorins in the Pathogenesis of Inflammatory Bowel Diseases (IBDs).PloS one · 2015Article
- Semaphorins: their dual role in regulating immune-mediated diseases.Clinical reviews in allergy & immunology · 2014Review
- Semaphorins and plexins as therapeutic targets.Nature reviews. Drug discovery · 2014Review
- Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation.Molecular immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
To define the role of semaphorin 4A (Sema4A) in allergic response, we employed Sema4A⁻/⁻ and wild-type (WT) mice in the experimental model of ovalbumin (OVA)-induced allergic airway inflammation. We observed a selective increase in eosinophilic airway infiltration accompanied by bronchial epithelial cell hyperplasia in allergen-treated Sema4A⁻/⁻ mice relative to WT mice. This enhanced inflammatory response was associated with a selective increase in bronchoalveolar lavage (BAL) interleukin 13 (IL-13) content, augmented airway hyperreactivity, and lower regulatory T cell (Treg) numbers. In vivo allergen-primed Sema4A⁻/⁻ CD4+ T cells were more effective in transferring T helper type 2 (Th2) response to naive mice as compared with WT CD4+ T cells. T-cell proliferation and IL-13 productions in OVA₃₂₃₋₃₃₉-restimulated Sema4A⁻/⁻ cell cultures were upregulated. Generated bone marrow chimeras showed an equal importance of both lung-resident cell and inflammatory cell Sema4A expression in optimal disease regulation. These data provide a new insight into Sema4A biology and define Sema4A as an important regulator of Th2-driven lung pathophysiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.