ArticleBMC veterinary research2012
Transmissibility of caprine scrapie in ovine transgenic mice.
Article in BMC veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains.Scientific reports · 2020Article
- Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System.Antimicrobial agents and chemotherapy · 2016Article
- Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein.The Journal of general virology · 2016Article
- A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation.Prion · 2016Article
- Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion.The Journal of general virology · 2016Article
- Role of the PRNP S127 allele in experimental infection of goats with classical caprine scrapie.Animal genetics · 2015Article
- Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays.Journal of veterinary science · 2015Article
- Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep.BMC veterinary research · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe United States control program for classical ovine scrapie is based in part on the finding that infection is typically spread through exposure to shed placentas from infected ewes. Transmission from goats to sheep is less well described. A suitable rodent model for examining the effect of caprine scrapie isolates in the ovine host will be useful in the ovine scrapie eradication effort. In this study, we describe the incubation time, brain lesion profile, glycoform pattern and PrPSc distribution patterns in a well characterized transgenic mouse line (Tg338) expressing the ovine VRQ prion allele, following inoculation with brain from scrapie infected goats.
resultsFirst passage incubation times of caprine tissue in Tg338 ovinized mice varied widely but second passage intervals were shorter and consistent. Vacuolation profiles, glycoform patterns and paraffin-embedded tissue blots from terminally ill second passage mice derived from sheep or goat inocula were similar. Proteinase K digestion products of murine tissue were slightly smaller than the original ruminant inocula, a finding consistent with passage of several ovine strains in previous reports.
conclusionsThese findings demonstrate that Tg338 mice propagate prions of caprine origin and provide a suitable baseline for examination of samples identified in the expanded US caprine scrapie surveillance program.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.