ArticleBMC evolutionary biology2012
Different selective pressures lead to different genomic outcomes as newly-formed hybrid yeasts evolve.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 58 citations in OpenAlex.
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- Beer yeast breeding in the era of innovation: advances and applications for modern brewing.Biotechnology letters · 2025Review
- Distinct genome stabilization procedures lead to phenotypic variability in newly generated interspecific yeast hybrids.Frontiers in microbiology · 2025Article
- Loss of Heterozygosity and Its Importance in Evolution.Journal of molecular evolution · 2023Review
- Experimental evolution ofmicroPublication biology · 2023Article
- Lager Yeast Design Through Meiotic Segregation of aFrontiers in fungal biology · 2021Article
- The evolving species concepts used for yeasts: from phenotypes and genomes to speciation networks.Fungal diversity · 2021Review
- Applications of Wild Isolates ofFrontiers in microbiology · 2020Review
- Wild Yeast for the Future: Exploring the Use of Wild Strains for Wine and Beer Fermentation.Frontiers in genetics · 2020Review
- Differential Contribution of the Parental Genomes to aFrontiers in bioengineering and biotechnology · 2020Article
- Yeast two- and three-species hybrids and high-sugar fermentation.Microbial biotechnology · 2019Review
- Fitness benefits of loss of heterozygosity inGenome research · 2019Article
- Adaptation by Loss of Heterozygosity inGenetics · 2019Article
- Aneuploidy in yeast: Segregation error or adaptation mechanism?Yeast (Chichester, England) · 2019Article
- Temperature preference can bias parental genome retention during hybrid evolution.PLoS genetics · 2019Article
- Phenotype-Independent Isolation of InterspeciesFrontiers in microbiology · 2019Article
- Article
- Enhanced Wort Fermentation withApplied and environmental microbiology · 2018Article
- Interspecies Hybridisation and Genome Chimerisation inFrontiers in microbiology · 2018Review
- Can Interspecies Hybrid Zygosaccharomyces rouxii Produce an Allohaploid Gamete?Applied and environmental microbiology · 2018Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
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Abstract
backgroundInterspecific hybridization occurs in every eukaryotic kingdom. While hybrid progeny are frequently at a selective disadvantage, in some instances their increased genome size and complexity may result in greater stress resistance than their ancestors, which can be adaptively advantageous at the edges of their ancestors' ranges. While this phenomenon has been repeatedly documented in the field, the response of hybrid populations to long-term selection has not often been explored in the lab. To fill this knowledge gap we crossed the two most distantly related members of the Saccharomyces sensu stricto group, S. cerevisiae and S. uvarum, and established a mixed population of homoploid and aneuploid hybrids to study how different types of selection impact hybrid genome structure.
resultsAs temperature was raised incrementally from 31°C to 46.5°C over 500 generations of continuous culture, selection favored loss of the S. uvarum genome, although the kinetics of genome loss differed among independent replicates. Temperature-selected isolates exhibited greater inherent and induced thermal tolerance than parental species and founding hybrids, and also exhibited ethanol resistance. In contrast, as exogenous ethanol was increased from 0% to 14% over 500 generations of continuous culture, selection favored euploid S. cerevisiae x S. uvarum hybrids. Ethanol-selected isolates were more ethanol tolerant than S. uvarum and one of the founding hybrids, but did not exhibit resistance to temperature stress. Relative to parental and founding hybrids, temperature-selected strains showed heritable differences in cell wall structure in the forms of increased resistance to zymolyase digestion and Micafungin, which targets cell wall biosynthesis.
conclusionsThis is the first study to show experimentally that the genomic fate of newly-formed interspecific hybrids depends on the type of selection they encounter during the course of evolution, underscoring the importance of the ecological theatre in determining the outcome of the evolutionary play.
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