ArticleJournal of natural products2012
Universal quantification of structurally diverse natural products using an evaporative light scattering detector.
Article in Journal of natural products, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Halogenation-Guided Chemical Screening Uncovers Cyanobacterin Analogues from the CyanobacteriumJournal of natural products · 2025Article
- Aetokthonotoxin, the Causative Agent of Vacuolar Myelinopathy, Uncouples Oxidative Phosphorylation due to Protonophore Activity.Chemical research in toxicology · 2025Article
- Recent Advances in the Characterization of Food Biomacromolecules: Polysaccharide, Protein, and Lipid.Food science & nutrition · 2025Review
- Mining for Halogenated Metabolites ofJournal of natural products · 2025Article
- Derivatization of Microcystins Can Increase Target Inhibition while Reducing Cellular Uptake.Journal of natural products · 2025Article
- Dereplication of Natural Product Antifungals via Liquid Chromatography-Tandem Mass Spectrometry and Chemical Genomics.Molecules (Basel, Switzerland) · 2024Article
- High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery.Metabolites · 2023Review
- UPLC-PDA-ESI-QTOF-MS/MS and GC-MS analysis of IranianFood science & nutrition · 2021Article
- A marine microbiome antifungal targets urgent-threat drug-resistant fungi.Science (New York, N.Y.) · 2020Article
- Halogenation-Guided Chemical Screening Provides Insight into Tjipanazole Biosynthesis by the Cyanobacterium Fischerella ambigua.Chembiochem : a European journal of chemical biology · 2020Article
- The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species.Fitoterapia · 2019Article
- Chemical Profile and Safety Assessment of a Food-Grade Acetogenin-Enriched Antimicrobial Extract from Avocado Seed.Molecules (Basel, Switzerland) · 2019Article
- Biemamides A-E, Inhibitors of the TGF-β Pathway That Block the Epithelial to Mesenchymal Transition.Organic letters · 2018Article
- Micromonohalimanes A and B: Antibacterial Halimane-Type Diterpenoids from a Marine Micromonospora Species.Journal of natural products · 2016Article
- Evaporative light scattering quantification of natural products possessing a carbon-phosphorus bond.The Journal of antibiotics · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A lack of good methods for absolute quantification of natural products has limited the accuracy of high-throughput screening. Many currently used methods for quantification are either too slow or not amenable to the structural diversity of natural products. Recent developments in low-temperature evaporative light scattering detectors (ELSD-LT) have overcome several historical limitations of ELSDs, including analyte decomposition and low sensitivity. Primarily, ELSDs have been used for relative quantification and detection of compounds that lack a UV chromophore. In this study, we employ an ELSD-LT for absolute quantification of natural products. Calibration curves were constructed using a weighted least-squares analysis for a diverse set of natural products and other compounds. An average calibration curve was evaluated for the "universal" quantification of natural products. Optimization of ELSD-LT hardware and parameters improved sensitivity and throughput and established the utility of ELSD-LT for quantification of large natural product libraries.
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Registered trials
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