ArticleGenes, brain, and behavior2012
Running-induced anxiety is dependent on increases in hippocampal neurogenesis.
Article in Genes, brain, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Acute forced exercise increases Bdnf IV mRNA and reduces exploratory behavior in C57BL/6J mice.Genes, brain, and behavior · 2020Article
- Adult Neurogenesis, Glia, and the Extracellular Matrix.Cell stem cell · 2019Review
- α4-GABAMolecular and cellular neurosciences · 2018Article
- Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression.Translational psychiatry · 2017Article
- The Long Run: Neuroprotective Effects of Physical Exercise on Adult Neurogenesis from Youth to Old Age.Current neuropharmacology · 2017Review
- Anxiolytic Actions of Exercise in Absence of New Neurons.Hippocampus · 2016Article
- Enhanced anxiety in the male offspring of sires that self-administered cocaine.Addiction biology · 2016Article
- Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety.Molecular brain · 2015Article
- Oral self-administration of EtOH: sex-dependent modulation by running wheel access in C57BL/6J mice.Alcoholism, clinical and experimental research · 2014Article
- Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.Molecular psychiatry · 2014Article
- Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia.Neuroscience · 2014Article
- Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.Synapse (New York, N.Y.) · 2013Article
- Divergent functional effects of sazetidine-a and varenicline during nicotine withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain.Neural regeneration research · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
Exercise, specifically voluntary wheel running, is a potent stimulator of hippocampal neurogenesis in adult mice. In addition, exercise induces behavioral changes in numerous measures of anxiety in rodents. However, the physiological underpinnings of these changes are poorly understood. To investigate the role of neurogenesis in exercise-mediated anxiety, we examined the cellular and behavioral effects of voluntary wheel running in mice with a reduction in hippocampal neurogenesis, achieved through conditional deletion of ataxia telangiectasia-mutated and rad-3-related protein (ATR), a cell cycle checkpoint kinase necessary for normal levels of neurogenesis. Following hippocampal microinjection of an adeno-associated virus expressing Cre recombinase to delete ATR, mice were exposed to 4 weeks of voluntary wheel running and subsequently evaluated for anxiety-like behavior. Wheel running resulted in increased cell proliferation and neurogenesis, as measured by bromodeoxyuridine and doublecortin, respectively. Wheel running also resulted in heightened anxiety in the novelty-induced hypophagia, open field and light-dark box tests. However, both the neurogenic and anxiogenic effects of wheel running were attenuated following hippocampal ATR deletion, suggesting that increased neurogenesis is an important mediator of exercise-induced anxiety.
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