Evidence map›Paper›PMID 22471393›Full record

ReviewThe International journal of neuroscience2012

Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations.

Gabriel S Dichter, Linmarie Sikich, Allen Song, James Voyvodic, James W Bodfish

Abstract readReview
In one paragraph

Review in The International journal of neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Resting-state connectivity predictors of response to psychotherapy in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
    Article
  10. Classification of behaviorally defined disorders: biology versus the DSM.Journal of autism and developmental disorders · 2014
    Review
  11. Review
  12. Psychotherapy and brain plasticity.Frontiers in psychology · 2013
    Review
  13. The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gabriel S DichterDepartment of Psychiatry, University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599-7255, USA. dichter@med.unc.edu
Linmarie Sikich
Allen Song
James Voyvodic
James W Bodfish
Duke Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Functional Neuroimaging of Psychopharmacologic Intervention for AutismK23MH081285 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DICHTER, GABRIEL S · 2008 to 2012
$794k
NIMH NIH HHS K23 MH081285
6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI) has helped to elucidate the neurobiological bases of psychiatric and neurodevelopmental disorders by localizing etiologically-relevant aberrations in brain function. Functional MRI also has shown great promise to help understand potential mechanisms of action of effective treatments for a range of psychiatric and neurodevelopmental disorders, including mood and anxiety disorders, schizophrenia, and autism. However, the use of fMRI to probe intervention effects in psychiatry is associated with unique methodological considerations, including the psychometric properties of repeated fMRI scans, how to assess potential relations between the effects of an intervention on symptoms and on specific brain activation patterns, and how to best make causal inferences about intervention effects on brain function. Additionally, the study of treatment effects in neurodevelopmental disorders presents additional unique challenges related to brain maturation, analysis methods, and the potential for motion artifacts. We review these methodological considerations and provide recommendations for best practices for each of these topics.

Indexed as

BrainBrain MappingHallucinogensHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMental DisordersNeuropsychological TestsOxygenPsychometricsHallucinogensOxygen

Identifiers

PMID22471393
PMCPMC5650475
OpenAlexW2080125229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.